2,4,6-Trichlorobenzoic acid

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Names

[ CAS No. ]:
50-43-1

[ Name ]:
2,4,6-Trichlorobenzoic acid

[Synonym ]:
2,4,6-Trichlor-benzoesaeure
2,4,6-trichlorbenzoes
2,4,6-trichlorophenylcarboxylic acid
Benzoic acid, 2,4,6-trichloro-
2,3-DIHYDROBENZO[B]FURAN-5-CARBOXALDEHYDE O5-ETHYLOXIME
2,4,6-Trichlorobenzoicacid
2,4,6-Trichlorobenzoic acid
Benzoic acid,2,4,6-trichloro
MFCD00060699

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
329.7±37.0 °C at 760 mmHg

[ Melting Point ]:
160-164 °C(lit.)

[ Molecular Formula ]:
C₇H₃Cl₃O₂

[ Molecular Weight ]:
225.456

[ Flash Point ]:
153.2±26.5 °C

[ Exact Mass ]:
223.919861

[ PSA ]:
37.30000

[ LogP ]:
2.98

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.611

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH8050000

CHEMICAL NAME :: Benzoic acid, 2,4,6-trichloro-

CAS REGISTRY NUMBER :: 50-43-1

BEILSTEIN REFERENCE NO. :: 1874127

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C7-H3-Cl3-O2

MOLECULAR WEIGHT :: 225.45

WISWESSER LINE NOTATION :: QVR BG DG FG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 13,1538,1964

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DH8050000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,4,6-Trichlorobenzoyl chloride
2,4,6-Trichlorobenzonitrile
1,3,5-Trichlorobenzene
1,3,5-trichloro-2-(trifluoromethyl)benzene
Carbon dioxide
2,4,6-Trichlorophenol
1,3,5-trichloro-2-(trichloromethyl)benzene
1,3,5-trichloro-2-methylbenzene
3,3-dimethyl-1-(2,4,6-trichlorophenoxy)butan-2-one

DownStream

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Influence of organic carbon and metal oxide phases on sorption of 2,4,6-trichlorobenzoic acid under oxic and anoxic conditions.

Environ. Monit. Assess. 187(1) , 4170, (2015)

Chlorobenzoic acids represent crucial recalcitrant metabolites in the environment; thus, the influence of soil components on the sorption of 2,4,6-trichlorobenzoic acid (TCB) under oxic and anoxic con...

Phenoxy herbicides and fibrates potently inhibit the human chemosensory receptor subunit T1R3.

J. Med. Chem. 52 , 6931-5, (2009)

We show that phenoxyauxin herbicides and lipid-lowering fibrates inhibit human but not rodent T1R3. T1R3 as a coreceptor in taste cells responds to sweet compounds and amino acids; in endocrine cells ...

Impact of nutrient composition on a degradative biofilm community.

Appl. Environ. Microbiol. 63(6) , 2432-8, (1997)

A microbial community was cultivated in flow cells with 2,4,6-trichlorobenzoic acid (2,4,6-TCB) as sole carbon and energy source and was examined with scanning confocal laser microscopy and fluorescen...

9c as a mixed anhydride with 2,4,6-trichlorobenzoic acid
2,4,6-Trinitrophenylglutamic acid
2,4,6-Octatrienoic acid, 2,6-dimethyl-8-oxo-, ethyl ester
2,4,6-triiodobenzoic acid
2,4,6-Octatrienoic acid
2,4,6-Trimethylbenzeneboronic acid neopentyl glycol cyclic ester