2,4-Dichlorobenzoic acid

Names

[ CAS No. ]:
50-84-0

[ Name ]:
2,4-Dichlorobenzoic acid

[Synonym ]:
2,4-Dichlorbenzoic acid
Benzoic acid, 2,4-dichloro-
2,4-Dichlorobenzoic acid
MFCD00002414
EINECS 200-067-8

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
309.5±22.0 °C at 760 mmHg

[ Melting Point ]:
157-160 °C(lit.)

[ Molecular Formula ]:
C₇H₄Cl₂O₂

[ Molecular Weight ]:
191.012

[ Flash Point ]:
141.0±22.3 °C

[ Exact Mass ]:
189.958832

[ PSA ]:
37.30000

[ LogP ]:
2.81

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.599

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
0.36 g/L (15 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DG6650000

CHEMICAL NAME :: Benzoic acid, 2,4-dichloro-

CAS REGISTRY NUMBER :: 50-84-0

BEILSTEIN REFERENCE NO. :: 1868192

LAST UPDATED :: 199701

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C7-H4-Cl2-O2

MOLECULAR WEIGHT :: 191.01

WISWESSER LINE NOTATION :: QVR BG DG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: BCPCA6 Biochemical Pharmacology. (Pergamon Press Inc., Maxwell House, Fairview Park, Elmsford, NY 10523) V.1- 1958- Volume(issue)/page/year: 13,1538,1964

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: SKEZAP Shokuhin Eiseigaku Zasshi. Food Hygiene Journal. (Nippon Shokuhin Eisei Gakkai c/o Shokuhin Eisei Senta, 2-6-1 Jingumae, Shibuya-ku, Tokyo 150, Japan) V.1- 1960- Volume(issue)/page/year: 20,332,1979

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39-S22

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
DG6650000

[ HS Code ]:
2916399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,4-DICHLOROBENZYLALCOHOL
2,4-Dichlorotoluene
2,4-Dichlorobenzaldehyde
DICHLOROTOLUENE
2-bromo-4,6-dichlorobenzoic acid
2',4'-Dichloroacetophenone
Carbon dioxide
2,4-Dichloro-1-iodobenzene
2,4-dichloro-3-triethylsilylbenzoic acid

DownStream

4,7-dichloro-2-methylquinazoline
2,4,5-Trichlorobenzoic Acid
1,3-Dichloro-4,6-dinitrobenzene
Benzoic acid,2,4-dichloro-3,5-dinitro-
4-Chlorosalicylic acid
2-Chloro-4-hydroxybenzoic acid
METHYL 2,4-DICHLOROBENZOATE
4-Chloro-2-methoxybenzoic acid
1H-Benzimidazole,2-(2,4-dichlorophenyl)-
2-(Benzylsulfanyl)-4-chlorobenzoyl chloride

Preparation

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Ambigol C and 2,4-dichlorobenzoic acid, natural products produced by the terrestrial cyanobacterium Fischerella ambigua.

J. Nat. Prod. 68 , 459-61, (2005)

The new natural products 3,5-bis(2,4-dichlorophenoxy)-2,6-dichlorophenol (ambigol C, 1), a highly chlorinated aromatic compound, and 2,4-dichlorobenzoic acid (2) were isolated from the terrestrial cya...

NADPH-dependent reductive ortho dehalogenation of 2,4-dichlorobenzoic acid in Corynebacterium sepedonicum KZ-4 and Coryneform bacterium strainNTB-1 via 2,4-dichlorobenzoyl coenzyme A.

J. Bacteriol. 178(9) , 2656-61, (1996)

Corynebacterium sepedonicum KZ-4, described earlier as a strain capable of growth on 2,4-dichlorobenzoate (G.M. Zaitsev and Y.N. Karasevich, Mikrobiologiya 54:356-369, 1985), is known to metabolize th...

Automated dynamic liquid-liquid-liquid microextraction followed by high-performance liquid chromatography-ultraviolet detection for the determination of phenoxy acid herbicides in environmental waters.

J. Chromatogr. A. 1082(2) , 121-7, (2005)

Automated dynamic liquid-liquid-liquid microextraction (D-LLLME) controlled by a programmable syringe pump and combined with HPLC-UV was investigated for the extraction and determination of 5 phenoxy ...

2,4-Dichlorobenzoic acid-d3
3-Bromo-2,4-dichlorobenzoic acid
5-Amino-2,4-dichlorobenzoic acid
3-Cyano-2,4-dichlorobenzoic acid
3-Amino-2,4-dichlorobenzoic acid
6-amino-2,4-dichlorobenzoic acid
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-(4-chlorophenyl)acetate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 2-phenylbutanoate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 1-(4-chlorophenyl)cyclopentanecarboxylate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-(N,N-dimethylsulfamoyl)benzoate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-(N,N-diethylsulfamoyl)benzoate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-(pyrrolidin-1-ylsulfonyl)benzoate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-(piperidin-1-ylsulfonyl)benzoate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 4-(morpholinosulfonyl)benzoate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl 5-bromofuran-2-carboxylate
6-(((5-(2-ethylbutanamido)-1,3,4-thiadiazol-2-yl)thio)methyl)-4-oxo-4H-pyran-3-yl benzofuran-2-carboxylate

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