Thymidine
Suppliers
Names
[ CAS No. ]:
50-89-5
[ Name ]:
Thymidine
[Synonym ]:
1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-5-methyl-2,4(1H,3H)-pyrimidinedione
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-5-methyl-2(1H)-pyrimidinone
Thymidine
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-5-methylpyrimidin-2(1H)-one
2'-deoxy-5-methyluridine
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-.β.-D-erythro-pentofuranosyl)-5-methyl-
T6NVMVJ E1 A- ET5OTJ B1Q CQ &&Ribo Form
2,4(1H,3H)-Pyrimidinedione,1-(2-deoxy-.Beta.-D-erythro-pentofuranosyl)-5-methyl
SS-THYMIDINE
2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-5-methyl-
Thyminedeoxyriboside
2'-dT
1-(2-Deoxy-b-D-ribofuranosyl)-5-methyluracil
Zidovudine Related Compound D
EINECS 200-070-4
deoxyribosylthymine
deoxythymidine
DTHD
1-(2-Deoxy-β-D-ribofuranosyl)-5-methyluracil
Thymine-2-deoxyriboside
1-(2-Deoxy-β-D-erythro-pentofuranosyl)-5-methylpyrimidin-2,4(1H,3H)-dion
2'-Deoxythymidine
Thymine deoxyriboside
2(1H)-pyrimidinone, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-5-methyl-
3,4-Dihydrothymidine, 2'-deoxy-
2'-deoxy-5-methyl-Uridine
5-Methyldeoxyuridine
3H-Thymidine
1-(2-Deoxy-b-D-erythro-pentofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione
Dthyd
1-(2-Deoxy-β-D-ribofuranosyl)thymine
MFCD00006537
5-methyl-2'-deoxyuridine
b-Thymidine
Thymidin
Chemical & Physical Properties
[ Density]:
1.6±0.1 g/cm3
[ Boiling Point ]:
510.1±60.0 °C at 760 mmHg
[ Melting Point ]:
187-189ºC
[ Molecular Formula ]:
C10H14N2O5
[ Molecular Weight ]:
242.229
[ Flash Point ]:
262.3±32.9 °C
[ Exact Mass ]:
242.090271
[ PSA ]:
104.55000
[ LogP ]:
-0.90
[ Vapour Pressure ]:
0.0±3.0 mmHg at 25°C
[ Index of Refraction ]:
1.674
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- XP2071000
- CHEMICAL NAME :
- Thymidine
- CAS REGISTRY NUMBER :
- 50-89-5
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 28
- MOLECULAR FORMULA :
- C10-H14-N2-O5
- MOLECULAR WEIGHT :
- 242.26
- WISWESSER LINE NOTATION :
- T6NVMVJ E1 A- ET5OTJ B1Q CQ
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2512 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 400 mg/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 20 gm/kg
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Parenteral
- DOSE :
- 800 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Unscheduled DNA synthesis
- TYPE OF TEST :
- DNA inhibition
- TYPE OF TEST :
- Cytogenetic analysis
- TYPE OF TEST :
- Sperm Morphology
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Mammal - species unspecified Lymphocyte
- DOSE/DURATION :
- 150 mmol/L
- REFERENCE :
- PNASA6 Proceedings of the National Academy of Sciences of the United States of America. (National Academy of Sciences, Printing & Pub. Office, 2101 Constitution Ave., Washington, DC 20418) V.1- 1915- Volume(issue)/page/year: 48,686,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X7245 No. of Facilities: 213 (estimated) No. of Industries: 2 No. of Occupations: 3 No. of Employees: 578 (estimated) No. of Female Employees: 141 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi: Irritant;
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
XP2071000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
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