Nordihydroguaiaretic acid

Suppliers

Names

[ CAS No. ]:
500-38-9

[ Name ]:
Nordihydroguaiaretic acid

[Synonym ]:
1,2-Benzenediol, 4-[(2R,3S)-4-(3,4-dihydroxyphenyl)-2,3-dimethylbutyl]-
meso-4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol
MFCD00002206
1,4-Bis(3,4-dihydroxyphenyl)-2,3-dimethylbutane
Nordihydroguaiaretic acid
Nordihydroguaiaretic acid (meso-form)
MESO-NORDIHYDROGUAIARETIC ACID
Nordihydroguairaretic acid
4,4'-(2,3-Dimethyltetramethylene)dipyrocatechol
Actinex
NDGA
4-[(2R,3S)-4-(3,4-Dihydroxyphenyl)-2,3-dimethylbutyl]-1,2-benzenediol
b,g-Dimethyl-a,d-bis(3,4-dihydroxyphenyl)butane
Masoprocol
4-[(2R,3S)-4-(3,4-Dihydroxyphenyl)-2,3-dimethylbutyl]benzene-1,2-diol
1,2-Benzenediol,4,4'-(2,3-dimethyl-1,4-butanediyl)bis-
Nordihydro Guaiaretic Acid
EINECS 207-903-0

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
526.5±45.0 °C at 760 mmHg

[ Melting Point ]:
184-189ºC

[ Molecular Formula ]:
C₁₈H₂₂O₄

[ Molecular Weight ]:
302.365

[ Flash Point ]:
247.8±23.3 °C

[ Exact Mass ]:
302.151794

[ PSA ]:
80.92000

[ LogP ]:
3.71

[ Vapour Pressure ]:
0.0±1.4 mmHg at 25°C

[ Index of Refraction ]:
1.627

[ Storage condition ]:
Freezer (-20°C)

[ Stability ]:
Stable. Incompatible with oxidizing agents.

[ Water Solubility ]:
slightly soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UX1750000

CHEMICAL NAME :: Pyrocatechol, 4,4'-(2,3-dimethyltetramethylene)di-

CAS REGISTRY NUMBER :: 500-38-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C18-H22-O4

MOLECULAR WEIGHT :: 302.40

WISWESSER LINE NOTATION :: QR BQ D1Y1&Y1&1R CQ DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 550 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 830 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Mutation test systems - not otherwise specified

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 35300 ug/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 412,139,1998

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UX1750000

[ HS Code ]:
2907299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2907299090

[ Summary ]:
2907299090 polyphenols; phenol-alcohols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0%

Articles

Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression.

J. Cell Biol. 210 , 23-33, (2015)

Proteins associated with the centrosome play key roles in mitotic progression in mammalian cells. The activity of Cdk1-opposing phosphatases at the centrosome must be inhibited during early mitosis to...

Inhibitors of the 5-lipoxygenase arachidonic acid pathway induce ATP release and ATP-dependent organic cation transport in macrophages

Biochim. Biophys. Acta 1838(7) , 1967-77, (2014)

We have previously described that arachidonic acid (AA)-5-lipoxygenase (5-LO) metabolism inhibitors such as NDGA and MK886, inhibit cell death by apoptosis, but not by necrosis, induced by extracellul...

All-trans retinoic acid prevents oxidative stress-induced loss of renal tight junction proteins in type-1 diabetic model.

J. Nutr. Biochem. 26 , 441-54, (2015)

We previously reported that diabetes decreased the expression of renal tight junction (TJ) proteins claudin-5 in glomerulus, and claudin-2 and occludin in proximal tubule through an oxidative stress d...