Rilpivirine

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Names

[ CAS No. ]:
500287-72-9

[ Name ]:
Rilpivirine

[Synonym ]:
[3H]-Rilpivirine
Edurant
Rilpivirine
TMC-278
4-[[4-[4-[(E)-2-cyanoethenyl]-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile
4-{[4-({4-[(E)-2-Cyanovinyl]-2,6-dimethylphenyl}amino)-2-pyrimidinyl]amino}benzonitrile
Benzonitrile, 4-[[4-[[4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]-
UNII-FI96A8X663
R 278474
BENZONITRILE,4-((4-((4-((1E)-2-CYANOETHEN YL)-2,6-DIMETHYLPHENYL)AMINO)-2-PYRIMIDINYL)AMINO)-)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
634.1±65.0 °C at 760 mmHg

[ Melting Point ]:
245ºC

[ Molecular Formula ]:
C22H18N6

[ Molecular Weight ]:
366.418

[ Flash Point ]:
337.3±34.3 °C

[ Exact Mass ]:
366.159302

[ PSA ]:
97.42000

[ LogP ]:
3.63

[ Vapour Pressure ]:
0.0±1.9 mmHg at 25°C

[ Index of Refraction ]:
1.665

[ Storage condition ]:
Refrigerator

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Aminobenzonitrile
  • 4-[(4-Chloro-2-pyrimidinyl)amino]benzonitrile
  • 4-bromo-2,6-xylidine
  • Ethyl 4-amino-3,5-dimethylbenzoate
  • 4-[[4-[4-(hydroxymethyl)-2,6-dimethylanilino]pyrimidin-2-yl]amino]benzonitrile
  • ETHYL 4-(2-(4-CYANOPHENYLAMINO)PYRIMIDIN-4-YLAMINO)-3,5-DIMETHYLBENZOATE
  • 2,6-xylidine
  • 4-iod-2,6-dimethylanilin
  • 4-(4-methoxypyrimidin-2-ylamino)benzonitrile

DownStream

  • rilpivirine hydrochloride

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • Rilpivirine-d6
  • Rilpivirine HCl
  • RILPIVIRINE FUMARATE SALT [1:1]
  • Despropenenitrile Bromo Rilpivirine
  • phenyl N-{1-[(chlorosulfonyl)methyl]bicyclo[2.2.1]heptan-2-yl}carbamate
  • (3-methyl-1-phenyl-1H-pyrazol-4-yl)methanesulfonyl fluoride
  • (1-cyclobutyl-3-methyl-1H-pyrazol-4-yl)methanesulfonyl fluoride
  • Benzyl 4-[(chlorosulfonyl)methyl]-3-phenylpiperidine-1-carboxylate
  • benzyl N-[3-(chlorosulfonyl)-1-(2-fluorophenyl)propyl]carbamate
  • 2-(Trimethylsilyl)-1,3-thiazole-4-sulfonyl fluoride
  • (6-Tert-butyl-1,4-dioxan-2-yl)methanesulfonyl fluoride
  • 1H-pyrazolo[4,3-b]pyridine-5-sulfonyl fluoride
  • 7-methoxy-1H-indazole-3-sulfonyl fluoride
  • 1-(4-chloro-3-methylphenyl)-1H-pyrazole-5-sulfonyl chloride
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