4-Hydroxybutanoic acid sodium salt

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Names

[ CAS No. ]:
502-85-2

[ Name ]:
4-Hydroxybutanoic acid sodium salt

[Synonym ]:
GHB
Sodium 4-hydroxybutanoate
Xyrem
4-Hydroxybutyrate sodium
Butanoic acid, 4-hydroxy-, sodium salt (1:1)
Sodium Oxybate
GHB SODIUM SALT
Butanoic acid, 4-hydroxy-, monosodium salt
Butanoic acid, 4-hydroxy-, sodium salt
gammaoh
MFCD00004402
γ-OH
SODIUM 4-HYDROXYBUTYRATE
γ-Hydroxybutyrate sodium
wy-3478
4-Hydroxybutanoic Acid Monosodium Salt
4-Hydroxybutyric acid monosodium salt
Sodium γ-hydroxybutyrate
Butyric acid, 4-hydroxy-, monosodium salt (8CI)
somsanit
γ-Hydroxybutyric acid monosodium salt
Butyric acid, 4-hydroxy-, sodium salt
Butyric acid, 4-hydroxy-, monosodium salt
Sodium Oxybate [USAN]
4-Hydroxybutyric acid sodium salt
EINECS 207-953-3

Chemical & Physical Properties

[ Boiling Point ]:
295.6ºC at 760mmHg

[ Melting Point ]:
145-146ºC

[ Molecular Formula ]:
C₄H₈NaO₃+

[ Molecular Weight ]:
126.086

[ Flash Point ]:
146.8ºC

[ Exact Mass ]:
126.029289

[ PSA ]:
57.53000

[ Storage condition ]:
Controlled Substance, -20?C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ET4750000

CHEMICAL NAME :: Butyric acid, 4-hydroxy-, sodium salt

CAS REGISTRY NUMBER :: 502-85-2

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C4-H7-O3.Na

MOLECULAR WEIGHT :: 126.10

WISWESSER LINE NOTATION :: Q3VO &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - man

DOSE/DURATION :: 71 mg/kg

TOXIC EFFECTS :: Behavioral - hallucinations, distorted perceptions Behavioral - coma Gastrointestinal - nausea or vomiting

REFERENCE :: AJEMEN American Journal of Emergency Medicine. (WB Saunders, Philadelphia, PA) V.1- 1983- Volume(issue)/page/year: 9,321,1991

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 9690 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FATOAO Farmakologiya i Toksikologiya (Moscow). For English translation, see PHTXA6 and RPTOAN. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.2- 1939- Volume(issue)/page/year: 43,714,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1650 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 32,375,1977

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3300 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - alteration of classical conditioning Skin and Appendages - hair

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,30,1967 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

DOSE :: 40 mg/kg

SEX/DURATION :: female 68 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - other neonatal measures or effects

REFERENCE :: AJOGAH American Journal of Obstetrics and Gynecology. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63146) V.1- 1920- Volume(issue)/page/year: 100,72,1968

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Hazard Codes ]:
F,T

[ Risk Phrases ]:
11-23/24/25-39/23/24/25

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
UN1230 - class 3 - PG 2 - Methanol, solution

[ WGK Germany ]:
2

[ RTECS ]:
ET4750000

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

gamma-Butyrolactone
4-acetyloxybutanoic acid
4-hydroxybutyric acid
4-(Benzyloxy)butanoic acid
4-[bis(4-methoxyphenyl)-phenylmethoxy]butanoic acid
benzyl 4-hydroxybutanoate
Methyl 4-hydroxybutanoate

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

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