Diphosgene

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Names

[ CAS No. ]:
503-38-8

[ Name ]:
Diphosgene

[Synonym ]:
Diphosgen
perchloromethylformate
Trichloromethyl chloroformate
Trichlormethylchlorformiat
trichloromethyl chloroformiate
di-Phosgene
Disphosgene
Chloroformic acid trichloromethyl ester
MFCD00015553
Difosgen
Perstoff
EINECS 207-965-9
Diphosgene
Trichloromethyl carbonochloridate
trichloro-methanochloroformate
Carbonochloridic acid, trichloromethyl ester

Chemical & Physical Properties

[ Density]:
1.8±0.1 g/cm3

[ Boiling Point ]:
128.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-57 °C

[ Molecular Formula ]:
C2Cl4O2

[ Molecular Weight ]:
197.832

[ Flash Point ]:
32.2±24.9 °C

[ Exact Mass ]:
195.865234

[ PSA ]:
26.30000

[ LogP ]:
2.85

[ Vapour Pressure ]:
10.8±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.499

[ Water Solubility ]:
may decompose

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ7350000
CHEMICAL NAME :
Formic acid, chloro-, trichloromethyl ester
CAS REGISTRY NUMBER :
503-38-8
BEILSTEIN REFERENCE NO. :
0970225
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C2-Cl4-O2
MOLECULAR WEIGHT :
197.82
WISWESSER LINE NOTATION :
GXGGOVG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LCLo - Lowest published lethal concentration
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
900 mg/m3/15M
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - ciliary function changes Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - other changes
REFERENCE :
FMORAO Folia Morphologica (Prague). (Plenum Pub. Corp. 233 Spring St., New York, NY 10013) V.13- 1965- Volume(issue)/page/year: 19,5,1971

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300 + H330-H314

[ Precautionary Statements ]:
P260-P264-P280-P284-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R26/27/28;R34

[ Safety Phrases ]:
S26-S28-S36/37/39-S45-S28A

[ RIDADR ]:
UN 3277 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
LQ7350000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Methyl chloroformate
  • methyl formate
  • Chloromethyl chloroformate
  • Triphosgene
  • Chlorine

DownStream

  • 2-Nitrophenyl isocyanate
  • 4-Chloro-3-(trifluoromethyl)phenylisocyanate
  • Heptyl Isocyanate
  • 5-Fluoroisatonic anhydride
  • 3-nitrophenyl isocyanate
  • N-(4-(2,5-Dioxo-4-oxazolidinyl)butyl)-2,2,2-trifluoroacetamide
  • 1-isocyanato-2-methyl-4-nitrobenzene
  • Isocyanatomethylbenzene
  • Ethanone,1-(4-isocyanatophenyl)-
  • 5-Benzyl L-glutamate N-carboxyanhydride

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Simple, rapid, and highly sensitive detection of diphosgene and triphosgene by spectrophotometric methods.

Talanta 80(1) , 231-5, (2009)

Methods for the detection and estimation of diphosgene and triphosgene are described. These compounds are widely used phosgene precursors which produce an intensely colored purple pentamethine oxonol ...

Acute nose-only inhalation exposure of rats to di- and triphosgene relative to phosgene.

Inhal. Toxicol. 23(2) , 65-73, (2011)

Groups of young adult Wistar rats were acutely exposed to trichloromethyl chloroformate (diphosgene) and bis(trichloromethyl) carbonate (triphosgene) vapor atmospheres using a directed-flow nose-only ...

Potential agents of chemical warfare. Worst-case scenario protection and decontamination methods.

Postgrad. Med. 112(5) , 133-40, (2002)


More Articles

Related Compounds

  • 2-{4-[(Morpholin-4-yl)methyl]phenyl}prop-2-en-1-amine
  • 2-[3-Chloro-4-(difluoromethoxy)phenyl]prop-2-en-1-amine
  • O-[(1-{6,6-dimethylbicyclo[3.1.1]hept-2-en-2-yl}cyclopropyl)methyl]hydroxylamine
  • {2,2-Difluoro-1-[1-(furan-2-yl)prop-1-en-2-yl]cyclopropyl}methanamine
  • 3-(4-Methylpyridin-2-yl)but-3-en-1-amine
  • 1-(5-bromo-1H-indol-2-yl)prop-2-en-1-one
  • (2E)-4-(dimethylamino)-N-{2-[5-(propan-2-yl)-1,3,4-thiadiazol-2-yl]ethyl}but-2-enamide
  • N-{1-azabicyclo[2.2.2]octan-3-yl}-N-[(2-methylphenyl)methyl]prop-2-enamide
  • 2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-5-ylsulfurofluoridate
  • 8-{2-[(2R)-2-hydroxyoctyl]cyclopropyl}octanoic acid
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