3-Methylbutanoic acid

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Names

[ CAS No. ]:
503-74-2

[ Name ]:
3-Methylbutanoic acid

[Synonym ]:
Butanoic acid, 3-methyl-
1,1-DIMETHYLPROPYL 3-METHYLBUTANOATE
Butanoic acid,3-methyl-,1,1-dimethylpropyl ester
Isovaleric acid
MFCD00002726
isobutanoic acid
3-Methylbutanoic acid
iso-valeric acid
3-Methyl-n-butyric acid
tert-Amyl isovalerate
β-methylbutyric acid
3-methyl butyric acid
2-Isovalerylamino-naphthalin
Isovaleriansaeure-tert-pentylester
3-Methylbutyric Acid
EINECS 207-975-3
QV1Y1&1
tert-Pentyl alcohol,isovalerate
3-Methylbutanoic acid,3-Methylbutyric acid
3-methyl-butanoic acid,1,1-dimethylpropyl ester
i-butanoic acid

Chemical & Physical Properties

[ Density]:
1.0±0.1 g/cm3

[ Boiling Point ]:
175.3±8.0 °C at 760 mmHg

[ Melting Point ]:
-35 °C

[ Molecular Formula ]:
C5H10O2

[ Molecular Weight ]:
102.132

[ Flash Point ]:
70.6±0.0 °C

[ Exact Mass ]:
102.068077

[ PSA ]:
37.30000

[ LogP ]:
1.13

[ Vapour Pressure ]:
0.6±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.418

[ Water Solubility ]:
25 g/L (20 ºC)

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NY1400000
CHEMICAL NAME :
Isovaleric acid
CAS REGISTRY NUMBER :
503-74-2
BEILSTEIN REFERENCE NO. :
1098522
LAST UPDATED :
199710
DATA ITEMS CITED :
12
MOLECULAR FORMULA :
C5-H10-O2
MOLECULAR WEIGHT :
102.15
WISWESSER LINE NOTATION :
QV1Y1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Open irritation test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/31/1972
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,841,1979
TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - rabbit
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/31/1972 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2 mL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/31/1972
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1120 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold
REFERENCE :
APTOA6 Acta Pharmacologica et Toxicologica. (Copenhagen, Denmark) V.1-59, 1945-86. For publisher information, see PHTOEH Volume(issue)/page/year: 18,141,1961
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
310 uL/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
UCDS** Union Carbide Data Sheet. (Union Carbide Corp., 39 Old Ridgebury Rd., Danbury, CT 06817) Volume(issue)/page/year: 1/31/1972 *** REVIEWS *** TOXICOLOGY REVIEW AMIHAB AMA Archives of Industrial Health. (Chicago, IL) V.11-21, 1955-60. For publisher information, see AEHLAU. Volume(issue)/page/year: 21,100,1960 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 84451 No. of Facilities: 35 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 69 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 84451 No. of Facilities: 148 (estimated) No. of Industries: 4 No. of Occupations: 16 No. of Employees: 6695 (estimated) No. of Female Employees: 1037 (estimated)

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P303 + P361 + P353-P304 + P340 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;T:Toxic;

[ Risk Phrases ]:
R22;R24;R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S38-S28A

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
NY1400000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2915600000

Synthetic Route

Precursor & DownStream

Precursor

  • 3,3-Dimethylacrylic acid
  • 4-Methyl-2-pentanone
  • 6-Methyl-2,4-heptanedione
  • 1-Bromo-2-methylpropane
  • Carbon dioxide
  • 3-Methyl-1-butanol
  • carbon monoxide
  • tert-Butanol

DownStream

  • 2-bromo-3-methyl-n-phenylbutanamide
  • 4-[(2R)-2-(Chloromethyl)-3-methylbutyl]-1-methoxy-2-(3-methoxypropoxy)benzene
  • PROPYL ISOPENTANOATE
  • 2-Hydroxy-2-methylbutyric acid
  • Aliskiren inter-7
  • isovaleric acid p-tolyl ester
  • 2,2-Dimethylbutanoic acid
  • 4-Methylpentanoic acid
  • 2-Hydroxy-3-methylbutyric acid
  • 2,3-DIISOPROPYLSUCCINIC ACID

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

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Related Compounds

  • 3-methylbutanoic acid
  • 2-imino-3-methylbutanoic acid
  • 2-ethyl-3-methylbutanoic acid
  • 3-azido-3-methylbutanoic acid
  • 2-amino-3-methylbutanoic acid
  • 3-bromo-3-methylbutanoic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 2-[(3-benzyl-4,8-dimethyl-2-oxo-2H-chromen-7-yl)oxy]-N-[2-(2-pyridyl)ethyl]acetamide
  • 1-(4-tert-butylphenyl)-2-(3-morpholin-4-ylpropyl)-4a,5,6,7,8,8a-hexahydro-1H-chromeno[2,3-c]pyrrole-3,9-dione
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • Methyl 7-methyl-1,2,3,4-tetrahydroquinoline-8-carboxylate
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde