Rosuvastatin Lactone

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Names

[ Name ]:
Rosuvastatin Lactone

[Synonym ]:
Methanesulfonamide, N-[4-(4-fluorophenyl)-6-(1-methylethyl)-5-[(E)-2-[(2S,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethenyl]-2-pyrimidinyl]-N-methyl-
RosuvastatinLactone
(3R,5R)-ROSUVASTATIN LACTONE
Rosuvastatin lactone
N-[4-(4-Fluorophenyl)-5-{(E)-2-[(2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl]vinyl}-6-isopropyl-2-pyrimidinyl]-N-methylmethanesulfonamide
ROSUVASTATIN-5S-LACTONE

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
695.0±65.0 °C at 760 mmHg

[ Melting Point ]:
131℃

[ Molecular Formula ]:
C₂₂H₂₆FN₃O₅S

[ Molecular Weight ]:
463.522

[ Flash Point ]:
374.1±34.3 °C

[ Exact Mass ]:
463.157715

[ PSA ]:
118.07000

[ LogP ]:
0.42

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.615

[ Storage condition ]:
-20℃

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Rosuvastatin
2-((4R,6S)-6-((E)-2-(4-(4-fluorophenyl )-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetate methyl ester
Rosuvastatin methanamine salt
tert-Butyl rosuvastatin
E-(6-{2-[2-(N-methyl-N-methanesulfonylamino)-4-(4-fluorophenyl)-6-isopropyl-pyrimidin-5-yl]vinyl}-[(4R,6S)-2,2-dimethyl-[1,3]dioxan-4-yl])-N-methoxy-N-methyl-acetamide
(6-{(E)-2-[4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl]vinyl}-(4R,6S)-2,2-dimethyl[1,3]dioxan-4-yl)-acetic acid ethyl ester
(4R-Cis)-6-Hydroxymethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester
4-(4-fluorophenyl)-6-isopropyl-2-[(n-methyl-n-methylsulfonyl)amino]pyriminl-5-yl-methanol

DownStream

Related Compounds

Rosuvastatin Lactone
(3R,5R)-Rosuvastatin Lactone
Rosuvastatin Anhydro Lactone
ROSUVASTATIN
Rosuvastatin
(+)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methylsulfonylamino)pyrimidin-5-yl]-(3R,5S)-dihydroxy-(E)-heptenoic acid morpholinium salt