Nafiverine

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Names

[ CAS No. ]:
5051-16-1

[ Name ]:
Nafiverine

Chemical & Physical Properties

[ Boiling Point ]:
670.9ºC at 760 mmHg

[ Molecular Formula ]:
C34H40Cl2N2O4

[ Molecular Weight ]:
611.59800

[ Flash Point ]:
359.5ºC

[ Exact Mass ]:
610.23700

[ PSA ]:
59.08000

[ LogP ]:
7.08400

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QJ1230000
CHEMICAL NAME :
1-Naphthaleneacetic acid, alpha-methyl-, 1,4-piperazinediyldi-2,1-ethanediyl ester, dihydrochloride
CAS REGISTRY NUMBER :
5051-16-1
LAST UPDATED :
199712
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C34-H38-N2-O4.2Cl-H
MOLECULAR WEIGHT :
611.66
WISWESSER LINE NOTATION :
L66J BY1&VO2- AT6N DNTJ D2OVY1&- BL66J &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5550 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,386,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,386,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1 gm/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,386,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
331 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex)
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,386,1966
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
82 mg/kg
TOXIC EFFECTS :
Behavioral - excitement Behavioral - ataxia
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 16,386,1966

Related Compounds

  • nafiverine
  • 2-(2-Fluoro-3-methylphenyl)-1-methylpiperazine
  • 5-(Diethylamino)-2-[(methylamino)methyl]phenol
  • 2-Thiophenepropanoic acid, 5-bromo-I(2),3-dimethyl-
  • (1R)-1-(3-bromo-5-methylthiophen-2-yl)ethan-1-amine
  • (1S)-1-(3-bromo-5-methylthiophen-2-yl)ethan-1-amine
  • 2-[(4-Hydroxyphenyl)methyl]pyrrolidine-2-carboxylic acid
  • 4-(aminomethyl)-N,N-diethyl-3-methoxyaniline
  • (1R)-1-(2-bromo-4,5-dimethoxyphenyl)ethan-1-ol
  • (1R)-1-{1H-pyrrolo[2,3-b]pyridin-3-yl}ethan-1-ol
  • 14-(Phenylmethyl) 2-tetradecenedioate
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