TPCA-1

Suppliers

Names

[ Name ]:
TPCA-1

[Synonym ]:
IKK-2 Inhibitor IV
5-(4-Fluorophenyl)-2-ureidothiophene-3-carboxamide
TPCA-1
2-(Carbamoylamino)-5-(4-fluorophenyl)-3-thiophenecarboxamide
2-(Carbamoylamino)-5-(4-fluorophenyl)thiophene-3-carboxamide
3qfv
GW683965 GW683965A [5-(p-Fluorophenyl)-2-ureido]thiophene-3-carboxamide
3-Thiophenecarboxamide, 2-[(aminocarbonyl)amino]-5-(4-fluorophenyl)-
2-((aminocarbonyl)amino)-5-(4-fluorophenyl)-3-thiophenecarboxamide

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
442.6±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₂H₁₀FN₃O₂S

[ Molecular Weight ]:
279.290

[ Flash Point ]:
221.5±28.7 °C

[ Exact Mass ]:
279.047760

[ PSA ]:
126.45000

[ LogP ]:
2.72

[ Appearance of Characters ]:
white to light brown

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.686

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: soluble5mg/mL, clear

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P301 + P312 + P330-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22-36

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

IKK2 inhibition using TPCA-1-loaded PLGA microparticles attenuates laser-induced choroidal neovascularization and macrophage recruitment.

PLoS ONE 10 , e0121185, (2015)

The inhibition of NF-κB by genetic deletion or pharmacological inhibition of IKK2 significantly reduces laser-induced choroid neovascularization (CNV). To achieve a sustained and controlled intraocula...

Breaking resistance of pancreatic cancer cells to an attenuated vesicular stomatitis virus through a novel activity of IKK inhibitor TPCA-1.

Virology 485 , 340-54, (2015)

Vesicular stomatitis virus (VSV) is an effective oncolytic virus against most human pancreatic ductal adenocarcinoma (PDAC) cell lines. However, some PDAC cell lines are highly resistant to oncolytic ...

Intestinal expression of Fas and Fas ligand is upregulated by bacterial signaling through TLR4 and TLR5, with activation of Fas modulating intestinal TLR-mediated inflammation.

J. Immunol. 193(12) , 6103-13, (2014)

TLRs play an important role in mediating intestinal inflammation and homeostasis. Fas is best studied in terms of its function in apoptosis, but recent studies demonstrate that Fas signaling may media...

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