3-(2-chloroethyl)(1H,3H)quinazoline-2,4-dione

Names

[ Name ]:
3-(2-chloroethyl)(1H,3H)quinazoline-2,4-dione

[Synonym ]:
3-(2-chloroethyl)-1H-quinazoline-2,4-dione
EINECS 225-795-3
3-(2-Chloroethyl)quinazoline-2,4(1H,3H)-dione
MFCD00044732

Chemical & Physical Properties

[ Density]:
1.358g/cm3

[ Melting Point ]:
195-197ºC(lit.)

[ Molecular Formula ]:
C₁₀H₉ClN₂O₂

[ Molecular Weight ]:
224.64400

[ Exact Mass ]:
224.03500

[ PSA ]:
54.86000

[ LogP ]:
0.92860

[ Index of Refraction ]:
1.581

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Hazard Codes ]:
T

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S23-S53-S24/25-S36-S37-S39

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-[3-(2-cloroethyl)ureido]benzonitrile
aminobenzonitrile
methyl 2-(2-chloroethylcarbamoylamino)benzoate
3-(2-hydroxyethyl)-1H,3H-quinazoline-2,4-dione
Ethyl chloroformate
2-Aminoethanol
ETHYL ANTHRANILATE
9-(2-chloroethylamino)-8-oxa-10-azabicyclo[4.4.0]deca-1,3,5,9-tetraen-7-one
2H-OXAZOLO[2,3-B]QUINAZOLIN-5(3H)-ONE

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Reinvestigation of the Synthesis of Ketanserin (5) and its Hydrochloride Salt (5. HCl) via 3-(2-Chloroethyl)-2,4-(1H,3H)-quinazolinedione (2) or Dihydro-5H-oxazole (2,3-b) quinazolin-5-one (1). Fakhraian H and Heydary M.

J. Heterocycl. Chem. 51(1) , 151-156, (2014)

3-(2-hydroxyethyl)-1H,3H-quinazoline-2,4-dione
3-(2-chloro-propyl)-1H-quinazoline-2,4-dione
3-(2-bromoethyl)-1H-quinazoline-2,4-dione
3-[2-(4-chlorophenyl)ethyl]-1H-quinazoline-2,4-dione
3-(2-piperidin-1-ylethyl)-1H-quinazoline-2,4-dione,hydrochloride
3-(2-chloro-1-methyl-ethyl)-1H-quinazoline-2,4-dione