L-Hydroxyproline

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Names

[ CAS No. ]:
51-35-4

[ Name ]:
L-Hydroxyproline

[Synonym ]:
4-Hydroxyproline
(2S,4R)-4-hydroxypyrrolidinium-2-carboxylate
Hydroxyproline
MFCD00064320
L-Hydroxyproline
trans-Lachnophyllol
trans-4-hydroxyproline
Proline, 4-hydroxy-, L-
trans-L-4-hydroxyproline
(2S,4R)-(-)-4-Hydroxypyrrolidine-2-carboxylic acid
Proline, 4-hydroxy-
trans-4-Hydroxy-L-proline
dec-2t-ene-4,6-diyn-1-ol
L-trans-4-hydroxyproline
(2S,4R)-4-Hydroxy-pyrrolidine-2-carboxylic acid
L-Proline, 4-hydroxy-, trans- (9CI)
L-Proline, 4-hydroxy-, (4R)-
Dec-2t-en-4,6-diin-1-ol
EINECS 200-091-9
rans-4-Hydroxy-L-proline
(-)-(2S,4R)-4-HYDROXYPROLINE
(2S,4R)-4-hydroxyproline
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid
4-Hydroxy-2-pyrrolidinecarboxylic acid
(trans)-4-Hydroxy-L-proline
(2S,4R)-trans-4-hydroxyproline
(4R)-4-Hydroxy-L-proline
L-Proline, 4-hydroxy-, trans-
(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid,Hyp

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
355.2±42.0 °C at 760 mmHg

[ Melting Point ]:
273 °C (dec.)(lit.)

[ Molecular Formula ]:
C₅H₉NO₃

[ Molecular Weight ]:
131.130

[ Flash Point ]:
168.6±27.9 °C

[ Exact Mass ]:
131.058243

[ PSA ]:
69.56000

[ LogP ]:
-1.84

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.540

[ Water Solubility ]:
357.8 g/L (20 º C)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TW3586500

CHEMICAL NAME :: Proline, 4-hydroxy-, L-

CAS REGISTRY NUMBER :: 51-35-4

LAST UPDATED :: 199806

DATA ITEMS CITED :: 1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lymphocyte

DOSE/DURATION :: 10 mg/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TW3586500

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Proline
Boc-L-Allylglycine
(2S,4S)-2-(tert-butoxycarbonyl)amino-4-bromomethyl-γ-butyrolactone
(2S,4R)-2-tert-butoxycarbonylamino-4-hydroxymethyl-4-butanolide
(2S,4S)-2-(tert-butoxycarbonyl)amino-3,4-epoxypentanoic acid methyl ester
(2R,5S,7R)-2-(tert-butyl)-4-oxo-3-oxa-1-azabicyclo[3.3.0]oct-7-yl acetate
trans-4-hydroxy-D,L-proline
Boc-Hyp-OMe
(R)-4-oxo-1,2-pyrrolidinedicarboxylic acid dimethyl ester

DownStream

1-[(3-nitrophenyl)methyl]pyrrole
1-[(4-nitrophenyl)methyl]pyrrole
1-(2-NITRO-PHENYL)-3-PHENYL-PIPERAZINE
(2S,4R)-METHYL 4-(TERT-BUTOXYCARBONYLAMINO)PYRROLIDINE-2-CARBOXYLATE
H-Hyp-OEt.HCl
1H-Pyrrole,1-(3-nitrophenyl)-
(4R)-1-(tert-Butoxycarbonyl)-4-methyl-L-proline
Boc-trans-4-cyano-L-proline methyl ester
n-boc-cis-4-cyano-l-proline methyl ester
L-ERYTHRO-4-FLUORO-GLUTAMIC ACID

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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