L-thyroxine
Suppliers
Names
[ CAS No. ]:
51-48-9
[ Name ]:
L-thyroxine
[Synonym ]:
Thyroxine (VAN)
b-((3,5-Diiodo-4-hydroxyphenoxy)-3,5-diiodophenyl)alanine
Thyroxine, L- (8CI)
EINECS 200-101-1
(-)-3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]alanine
3,3’,5,5‘’-Tetraiodo-L-thyronine
O-(4-Hydroxy-3,5-diiodophenyl)-3,5-diiodo-L-tyrosine
3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine
Thyroxine
L-3,5,3',5'-Tetraiodothyronine
thyroxine-binding globulin
(-)-Thyroxine
Thryroxine, l-
thyroxin
T4
L-Thyroxine
Tetraiodothyronine
THX
L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
transthyretin
L-Thyroxin
Thyroxine, L-
Thyrax
l-t4
Levothyroxine
3,5,3',5'-Tetraiodothyronine
O-(4-Hydroxy-3,5-diidophenyl)-3,5-diiodo-L-tyrosine
4-14-00-02373 (Beilstein Handbook Reference)
thyroxinal
L-thyroxine zwitterion
(2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoic acid
Henning
MFCD00002596
Chemical & Physical Properties
[ Density]:
2.6±0.1 g/cm3
[ Boiling Point ]:
576.3±50.0 °C at 760 mmHg
[ Melting Point ]:
235 °C
[ Molecular Formula ]:
C15H11I4NO4
[ Molecular Weight ]:
776.870
[ Flash Point ]:
302.3±30.1 °C
[ Exact Mass ]:
776.686646
[ PSA ]:
92.78000
[ LogP ]:
5.93
[ Vapour Pressure ]:
0.0±1.7 mmHg at 25°C
[ Index of Refraction ]:
1.795
[ Storage condition ]:
2~8°C
[ Water Solubility ]:
insoluble
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YP2833500
- CHEMICAL NAME :
- L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-
- CAS REGISTRY NUMBER :
- 51-48-9
- BEILSTEIN REFERENCE NO. :
- 2228515
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 15
- MOLECULAR FORMULA :
- C15-H11-I4-N-O4
- MOLECULAR WEIGHT :
- 776.87
- WISWESSER LINE NOTATION :
- QVYZ1R CI EI DOR DQ CI EI
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 63 ug/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Cardiac - pulse rate increase, without fall in BP
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 400 ug/kg/2D-I
- TOXIC EFFECTS :
- Behavioral - coma Cardiac - arrhythmias (including changes in conduction)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2 mg/kg/10D-I
- TOXIC EFFECTS :
- Liver - other changes Biochemical - Enzyme inhibition, induction, or change in blood or tissue levels - monoamine oxidase Biochemical - Metabolism (Intermediary) - effect on mitochondrial function
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 26250 ug/kg
- SEX/DURATION :
- female 1-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - eye/ear
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 1400 ug/kg
- SEX/DURATION :
- female 16-22 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Newborn - biochemical and metabolic
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 410 mg/kg
- SEX/DURATION :
- female 3 week(s) pre-mating female 1-20 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - cytological changes (including somatic cell genetic material)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 450 ug/kg
- SEX/DURATION :
- female 7-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 8160 ug/kg
- SEX/DURATION :
- female 7 day(s) pre-mating - 5 day(s) post-birth
- TOXIC EFFECTS :
- Reproductive - Maternal Effects - postpartum
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 600 ug/kg
- SEX/DURATION :
- female 19-21 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - urogenital system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Unreported
- DOSE :
- 12 mg/kg
- SEX/DURATION :
- male 6 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - mating performance (e.g. # sperm positive females per # females mated; # copulations per # estrus cycles)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 12 mg/kg
- SEX/DURATION :
- female 9-11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 6250 ug/kg/2D (Continuous)
- REFERENCE :
- BEXBAN Bulletin of Experimental Biology and Medicine (English Translation). Translation of BEBMAE. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) V.41- 1956- Volume(issue)/page/year: 72,942,1971 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M0234 No. of Facilities: 68 (estimated) No. of Industries: 1 No. of Occupations: 6 No. of Employees: 2770 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M0234 No. of Facilities: 717 (estimated) No. of Industries: 4 No. of Occupations: 9 No. of Employees: 10666 (estimated) No. of Female Employees: 7298 (estimated)
Safety Information
[ Symbol ]:
GHS02, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H301 + H311 + H331-H370
[ Precautionary Statements ]:
P210-P260-P280-P301 + P310 + P330-P302 + P352 + P312-P370 + P378
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R20/21/22
[ Safety Phrases ]:
S22-S24/25
[ RIDADR ]:
2811.0
[ WGK Germany ]:
3
[ RTECS ]:
YP2833500
[ Hazard Class ]:
6.1
[ HS Code ]:
2942000000
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922509090
[ Summary ]:
2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%
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