N-Acetyl Mesalazine

Suppliers

Names

[ CAS No. ]:
51-59-2

[ Name ]:
N-Acetyl Mesalazine

[Synonym ]:
CJ 46A
N-Acetyl Mesalazine
5-Acetamidosalicylic acid
N-Acetyl-5-aminosalicylic acid
3-Carboxyparacetamol
5-acetylamino salicylic acid
Acetylmesalazine 5-Acetamidosalicylic acid N-Acetyl-5-aminosalicylic acid
5-acetamido-2-hydroxy-benzoic acid

Chemical & Physical Properties

[ Density]:
1.462 g/cm3

[ Boiling Point ]:
480.2ºC at 760 mmHg

[ Melting Point ]:
228-230ºC

[ Molecular Formula ]:
C₉H₉NO₄

[ Molecular Weight ]:
195.17

[ Flash Point ]:
244.2ºC

[ Exact Mass ]:
195.05300

[ PSA ]:
86.63000

[ LogP ]:
1.12180

[ Index of Refraction ]:
1.661

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

5-Aminosalicylic Acid
Ethanoic anhydride
5-acetamido-2-acetyloxybenzoic acid
Acetamide
Salicylic acid, 5-nitro-
Salicylic acid
2-hydroxy-5-phenyl diazenyl benzoic acid
acetic acid

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Simultaneous determination of 5-aminosalicylic acid, acetyl-5-aminosalicylic acid and 2,5-dihydroxybenzoic acid in endoscopic intestinal biopsy samples in humans by high-performance liquid chromatography with electrochemical detection.

J. Pharm. Biomed. Anal. 14(1-2) , 175-80, (1995)

A high-performance liquid chromatographic method for the simultaneous determination of 5-aminosalicylic acid (5-ASA), acetyl-5-aminosalicylic acid (Ac-5-ASA) and 2,5-dihydroxybenzoic acid (5-HSA) in h...

Safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate active ulcerative colitis: results of a randomized, double-blind study.

J. Pediatr. Gastroenterol. Nutr. 49(5) , 571-9, (2009)

: A multicenter, double-blind study was conducted to evaluate the safety, efficacy, and pharmacokinetics of balsalazide in pediatric patients with mild-to-moderate ulcerative colitis (UC).: Sixty-eigh...

Radical-derived oxidation products of 5-aminosalicylic acid and N-acetyl-5-aminosalicylic acid.

J. Chromatogr. B, Biomed. Appl. 661(1) , 57-68, (1994)

5-Aminosalicylic acid is an agent effective in the treatment of chronic inflammatory bowel diseases. Its ability to scavenge radicals is considered to be a major factor responsible for its therapeutic...