4'-Methoxyacetanilide

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Names

[ CAS No. ]:
51-66-1

[ Name ]:
4'-Methoxyacetanilide

[Synonym ]:
Acetamide, N-(4-methoxyphenyl)-
methyl ether of paracetamol
4-(Acetylamino)anisole
p-Acetanisidine
N-Ac-4-methoxyaniline
acetaniside
4'-Methoxyacetanilide
MFCD00014963
2-methoxy-5-acetylamino-benzene
4-Acetaniside
4-acetylamino-anisole
N-(4-Methoxyphenyl)acetamide
Metacetin
P-ACETANISIDIDE
AURORA KA-3672
EINECS 200-114-2
METHACETIN
4-ACETANISIDINE
Acetanilide, 4'-methoxy-
N-(p-Methoxyphenyl)acetamide
p-acetaniside
4-ACETANISIDIDE
para-methoxyacetanilide

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
345.5±25.0 °C at 760 mmHg

[ Melting Point ]:
128-130 °C(lit.)

[ Molecular Formula ]:
C9H11NO2

[ Molecular Weight ]:
165.189

[ Flash Point ]:
162.8±23.2 °C

[ Exact Mass ]:
165.078979

[ PSA ]:
38.33000

[ LogP ]:
1.09

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.558

[ Water Solubility ]:
0.42 g/100 mL (20 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AE8290000
CHEMICAL NAME :
p-Acetanisidide
CAS REGISTRY NUMBER :
51-66-1
BEILSTEIN REFERENCE NO. :
0387887
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H11-N-O2
MOLECULAR WEIGHT :
165.21
WISWESSER LINE NOTATION :
1VMR DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 19,20,1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - body temperature increase
REFERENCE :
XPHBAO U.S. Public Health Service, Public Health Bulletin. (Washington, DC) Volume(issue)/page/year: 271,71,1941

Safety Information

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/38

[ Safety Phrases ]:
S36-S37/39-S26

[ WGK Germany ]:
1

[ RTECS ]:
AE8290000

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetanisole
  • Ethanone,1-(4-methoxyphenyl)-, oxime
  • p-Anisidine
  • acetic acid
  • Ethanoic anhydride
  • Acetyl chloride
  • Acetamide
  • 4-Iodoanisole
  • 1-Chloro-4-methoxybenzene
  • para-methoxyphenyl tosylate

DownStream

  • N-(1,4,4-trimethoxycyclohexa-2,5-dien-1-yl)acetamide
  • 5-Methoxy-2-benzimidazolethiol
  • Indometacin
  • 6-Hydroxyquinoline
  • 6-Methoxyquinoline
  • 4-Methoxy-3-nitroaniline
  • 1-(5-Amino-2-hydroxyphenyl)ethanone
  • 5-Acetylamino-2-methoxybenzenesulfonyl chloride
  • 2-Bromo-5-methoxyaniline
  • Acetamide,N-(4-methoxy-3-nitrophenyl)-

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 4'-methoxyacetanilide
  • 3'-Amino-4'-methoxyacetanilide
  • 3'-Ethylamino-4'-methoxyacetanilide
  • 2',6'-Dichloro-2-(diethylamino)-4'-methoxyacetanilide
  • 3'-[[Bis(2-chloroethyl)amino]methyl]-4'-methoxyacetanilide
  • 3'-[N,N-Bis(2-ethylcarbonyloxyethyl)amino]-4'-methoxyacetanilide
  • 2-Bromo-5-cyclopentyl-1,3,4-oxadiazole
  • 2-(5-Oxo-4,5-dihydro-1,3,4-oxadiazol-2-yl)benzoic acid
  • 2-(5-Methyl-2-oxo-2,3-dihydro-1,3,4-oxadiazol-3-yl)acetic acid
  • 7-Methoxy-2-oxa-6-azaspiro[3.4]oct-6-ene
  • 2-chloro-4-[3-(methoxymethyl)phenyl]-7H-pyrrolo[2,3-d]pyrimidine
  • 7-Bromoimidazo[1,5-a]pyridine-1-carboxylic acid
  • (1-(2-methoxyphenyl)-5-methyl-1H-1,2,3-triazol-4-yl)methanamine
  • 6-Bromo-3-methylimidazo[1,5-a]pyridine
  • 6-Bromo-3-isopropylimidazo[1,5-a]pyridine
  • 6-Methylimidazo[1,5-a]pyridine-1-carboxylic acid
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