Tyramine

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Names

[ CAS No. ]:
51-67-2

[ Name ]:
Tyramine

[Synonym ]:
Phenol, 4-(ethylamino)-
Uteramine
Tyramin
MFCD00008193
4-Ethylaminophenol
Tocosine
4-(2-aminoethyl)phenol
4-(2-aminoethyl)-pheno
p-Hydroxyphenylethylamine
Tyrosamine
Systogene
4-Hydroxyphenethylamine
p-Tyramine
4-(Ethylamino)phenol
4-(Ethylamino)benzolol
2-(4-Hydroxyphenyl)ethylamine
EINECS 200-115-8
4-hydroxy-phenethylamine

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
275.1±23.0 °C at 760 mmHg

[ Melting Point ]:
160-162 °C(lit.)

[ Molecular Formula ]:
C₈H₁₁NO

[ Molecular Weight ]:
137.179

[ Flash Point ]:
141.3±13.3 °C

[ Exact Mass ]:
137.084061

[ PSA ]:
46.25000

[ LogP ]:
1.38

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.600

[ Storage condition ]:
Refrigerator, Under Inert Atmosphere

[ Stability ]:
Stable. Incompatible with strong acids, strong oxidizing agents.

[ Water Solubility ]:
1g/95mL (15 ºC)

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SJ5950000

CHEMICAL NAME :: Phenol, p-(2-aminoethyl)-

CAS REGISTRY NUMBER :: 51-67-2

BEILSTEIN REFERENCE NO. :: 1099914

LAST UPDATED :: 199612

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C8-H11-N-O

MOLECULAR WEIGHT :: 137.20

WISWESSER LINE NOTATION :: Z2R DQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 225 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 229 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay)

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - sympathomimetic

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intracervical

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - muscle contraction or spasticity

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: Cytogenetic analysis

MUTATION DATA

TEST SYSTEM :: Rodent - mouse

DOSE/DURATION :: 137 mg/kg

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 240,19,1990

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36-S37/39

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
SJ5950000

[ HS Code ]:
2922299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

L-Tyrosine
(4-Hydroxyphenyl)acetaldehyd-dimethylhydrazon
N,N'-Disuccinimidyl carbonate
4-Hydroxyphenylacetonitrile
N-Acetyltyramine
N-{2-[4-(tetrahydro-2H-pyran-2-yloxy)phenyl]ethyl}formamide
4-Methoxyphenylethylamine
D-Thr-OH
Phenol

DownStream

5-[[2-(4-hydroxyphenyl)ethylamino]methyl]-2-methoxy-phenol
1,2,3,4-Tetrahydro-7-isoquinolinol
N,O-Diacetyltyramine
N-Acetyltyramine
4-(2-aminoethyl)-phenyl acetate
2-Cyclohexylethylamine
4-(2-Aminoethyl)cyclohexanol
2-(4-Benzyloxy-phenyl)-ethylamine
4-Hydroxyphenyl ethanol
dopamine

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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