Acipimox

Suppliers

Names

[ Name ]:
Acipimox

[Synonym ]:
5-methyl-2-pyrazinoic-4-oxide
2-Pyrazinecarboxylic acid, 5-methyl-, 4-oxide
2-Carboxy-5-methylpyrazine 4-oxide,5-Methylpyrazinecarboxylic acid 4-oxide
5-Carboxy-2-methylpyrazine 1-oxide
5-methyl-4-oxy-pyrazine-2-carboxylic acid
5-methylpyrazine-2-carboxylic acid 4-oxide
2-carboxy-5-methylpyrazine 4-oxide
Acipimox
K-9321
Olbetam
5-Methylpyrazinecarboxylic acid 4-oxide
5-Methyl-2-pyrazinecarboxylic acid 4-oxide
2-methyl-5-pyrazinecarboxylic acid 1-oxide
Olbemox
EINECS 256-928-3
T6N DNJ AO B1 EVQ
MFCD00865757

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
539.0±45.0 °C at 760 mmHg

[ Melting Point ]:
177-180 °C

[ Molecular Formula ]:
C₆H₆N₂O₃

[ Molecular Weight ]:
154.123

[ Flash Point ]:
279.8±28.7 °C

[ Exact Mass ]:
154.037842

[ PSA ]:
75.65000

[ LogP ]:
-1.38

[ Vapour Pressure ]:
0.0±1.5 mmHg at 25°C

[ Index of Refraction ]:
1.608

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UQ2453000

CHEMICAL NAME :: 2-Pyrazinecarboxylic acid, 5-methyl-, 4-oxide

CAS REGISTRY NUMBER :: 51037-30-0

BEILSTEIN REFERENCE NO. :: 0777471

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C6-H6-N2-O3

MOLECULAR WEIGHT :: 154.14

WISWESSER LINE NOTATION :: T6N DNJ AO B1 EVQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3500 mg/kg

TOXIC EFFECTS :: Biochemical - Metabolism (Intermediary) - lipids including transport

REFERENCE :: EJMCA5 European Journal of Medicinal Chemistry--Chimie Therapeutique. (Editions Scientifiques Elsevier, 29 rue Buffon, F-75005, Paris, France) V.9- 1974- Volume(issue)/page/year: 15,157,1980

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
UQ2453000

[ HS Code ]:
2942000000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Kinetics and utilization of lipid sources during acute exercise and acipimox.

Am. J. Physiol. Endocrinol. Metab. 307(2) , E199-208, (2014)

Overweight is associated with abnormalities of lipid metabolism, many of which are reversed by exercise. We investigated the impact of experimental antilipolysis and acute exercise on lipid kinetics a...

The lowering of hepatic fatty acid uptake improves liver function and insulin sensitivity without affecting hepatic fat content in humans.

Am. J. Physiol. Endocrinol. Metab. 295(2) , E413-9, (2008)

Lipolysis may regulate liver free fatty acid (FFA) uptake and triglyceride accumulation; both are potential causes of insulin resistance and liver damage. We evaluated whether 1) systemic FFA release ...

ECG-triggered 18F-fluorodeoxyglucose positron emission tomography imaging of the rat heart is dramatically enhanced by acipimox.

Eur. J. Nucl. Med. Mol. Imaging 37(9) , 1745-50, (2010)

18F-Fluorodeoxyglucose (FDG) imaging, provided by current positron emission tomography (PET) systems dedicated to small animals,might provide a precise functional assessment of the left ventricle (LV)...