N-Carbobenzoxy-4-aminobutyric Acid

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Names

[ Name ]:
N-Carbobenzoxy-4-aminobutyric Acid

[Synonym ]:
Butanoic acid, 4-[[(phenylmethoxy)carbonyl]amino]-
4-BENZYLOXYCARBONYLAMINO-BUTYRIC ACID
N-Carbobenzoxy-4-aMinobutyric Acid
4-{[(Benzyloxy)carbonyl]amino}butanoic acid
Z-GAMMA-ABU-OH
4-(phenylmethoxycarbonylamino)butanoic acid
N-Cbz-4-aminobutyric Acid
Z-GABA-OH

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
454.9±38.0 °C at 760 mmHg

[ Melting Point ]:
64ºC

[ Molecular Formula ]:
C₁₂H₁₅NO₄

[ Molecular Weight ]:
237.252

[ Flash Point ]:
228.9±26.8 °C

[ Exact Mass ]:
237.100113

[ PSA ]:
75.63000

[ LogP ]:
1.75

[ Appearance of Characters ]:
Solid

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.540

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: ES8137200

CHEMICAL NAME :: Butyric acid, 4-(carboxyamino)-, N-benzyl ester

CAS REGISTRY NUMBER :: 5105-78-2

BEILSTEIN REFERENCE NO. :: 1884426

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C12-H15-N-O4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Unreported

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1520 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BTMNA7 Bitamin. (Nippon Bitamin Gakkai, 4 Ushinomiya-cho, Yoshida, Sakyo-Ku, Kyoto 606, Japan) V.1- 1948- Volume(issue)/page/year: 25,297,1962

Safety Information

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26-S36-S37-S39

[ RTECS ]:
ES8137200

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Benzyl chloroformate
4-Aminobutanoic acid
methyl 4-(phenylmethoxycarbonylamino)butanoate
2-Methyl-2-propanyl 4-{[(benzyloxy)carbonyl]amino}butanoate
N-(Benzyloxycarbonyloxy)succinimide
Phenyl chloroformate
γ-(benzyloxycarbonylamino)butanoic acid ethyl ester

DownStream

N-CBZ-2-Pyrrolidinone
Butanoicacid, 4-[[(phenylmethoxy)carbonyl]amino]-, 4-nitrophenyl ester
1-Cbz-3-piperidinone
Carbamic acid,N,N'-1,6-hexanediylbis-, 1,1'-bis(phenylmethyl) ester
methyl 4-(phenylmethoxycarbonylamino)butanoate
4-[4-[4-(phenylmethoxycarbonylamino)butanoylamino]butanoylamino]butanoic acid
4-[methyl(phenylmethoxycarbonyl)amino]butanoic acid
2-Methyl-2-propanyl 4-{[(benzyloxy)carbonyl]amino}butanoate