Diosgenin

Suppliers

Names

[ CAS No. ]:
512-04-9

[ Name ]:
Diosgenin

[Synonym ]:
EINECS 208-134-3
3β-Hydroxy-5-spirostene
Diosgenin
(25R)-5-Spirosten-3β-ol
MFCD00016887
DELTA 5,20A,22A,25D-SPIROSTEN-3BETA-OL

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
527.1±50.0 °C at 760 mmHg

[ Melting Point ]:
205-208°C

[ Molecular Formula ]:
C27H42O3

[ Molecular Weight ]:
414.621

[ Flash Point ]:
272.6±30.1 °C

[ Exact Mass ]:
414.313385

[ PSA ]:
38.69000

[ LogP ]:
5.84

[ Vapour Pressure ]:
0.0±3.1 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
Refrigerator

[ Water Solubility ]:
chloroform: 20 mg/mL, clear, slightly yellow

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
WH1450000
CHEMICAL NAME :
Spirost-5-en-3-beta-ol, (25R)-
CAS REGISTRY NUMBER :
512-04-9
BEILSTEIN REFERENCE NO. :
0094582
LAST UPDATED :
199709
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C27-H42-O3
MOLECULAR WEIGHT :
414.69
WISWESSER LINE NOTATION :
T F5 E5 B666 HXO OUTJ A1 E1 G1 RQ H-& BT6OXTJ E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
4872 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>8 gm/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3564 mg/kg
TOXIC EFFECTS :
Behavioral - changes in motor activity (specific assay)
REFERENCE :
PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 11,1095,1977

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
WH1450000

[ HS Code ]:
2932999099

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Diosgenin glucoside
  • (25R)-Furosta-5,20(22)-diene-3β,26-diol
  • diosgenin, acetate
  • yamogenin
  • Cryptogenin
  • Gentrogenin
  • Neodiosgenin(3beta,25S) acetate
  • Dioscin

DownStream

  • Diosgenin benzoate
  • Polyphyllin D
  • cholesterol
  • Dehydroepiandrosterone
  • Dehydroepiandrosterone acetate
  • Tigogenin
  • Prosapogenin A
  • 16-Dehydropregenolone Acetate
  • 16-Dehydropregnenolone
  • (R)-5-Methyltetrahydro-2H-pyran-2-one

Customs

[ HS Code ]: 2932999099

[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Diosgenin-based thio(seleno)ureas and triazolyl glycoconjugates as hybrid drugs. Antioxidant and antiproliferative profile.

Eur. J. Med. Chem. 99 , 67-81, (2015)

The stereoselective preparation of diosgenin-derived thio(seleno)ureas and glycomimetics bearing a 1,2,3-triazolyl tether on C-3 has been accomplished. The key steps in the synthetic pathway are the i...

In Vivo Protective Effects of Diosgenin against Doxorubicin-Induced Cardiotoxicity.

Nutrients 7 , 4938-54, (2015)

Doxorubicin (DOX) induces oxidative stress leading to cardiotoxicity. Diosgenin, a steroidal saponin of Dioscorea opposita, has been reported to have antioxidant activity. Our study was aimed to find ...

The Chinese herb polyphyllin D sensitizes ovarian cancer cells to cisplatin-induced growth arrest.

J. Cancer Res. Clin. Oncol. 141(2) , 237-42, (2015)

We evaluated the effects of polyphyllin D (PD), a natural compound with anti-neoplastic activity and a major component of the Chinese herb Paris polyphylla, on ovarian cancer (OVCA) cell line prolifer...


More Articles

Related Compounds

  • Diosgenin
  • diosgenin
  • diosgenin
  • η-diosgenin
  • Diosgeninacetat
  • Glyco-diosgenin
  • 2-(m-Tolyl)-6,7-dihydro-5H-cyclopenta[d]pyrazolo[1,5-a]pyrimidin-8-ol
  • Thieno[2',3':4,5]pyrrolo[1,2-d][1,2,4]triazin-8(7h)-one
  • 3-Butyl-3H-imidazo[4,5-b]pyridine-2-thiol
  • 1-Benzyl-3-nitropyrrolidin-2-ol
  • 3-Cyclohexyl-3H-imidazo[4,5-b]pyridine-2-thiol
  • 5-amino-4-cyano-N-(2,4-dimethylphenyl)-3-methylthiophene-2-carboxamide
  • 4,7,8-Trimethyl-[1,2,4]triazolo[4,3-a]quinoline-1-thiol
  • 5-((4-Ethylphenoxy)methyl)-4-(p-tolyl)-4H-1,2,4-triazole-3-thiol
  • 6-Chloro-pyrazolo[1,5-A]pyrimidine-2-carbonylchloride
  • 4-(2-Ethoxyphenyl)-5-((4-ethylphenoxy)methyl)-4H-1,2,4-triazole-3-thiol
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