(D-Ala6)-LHRH acetate salt

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Names

[ CAS No. ]:
51230-19-4

[ Name ]:
(D-Ala6)-LHRH acetate salt

[Synonym ]:
(D-ALA6)-LHRH

Chemical & Physical Properties

[ Molecular Formula ]:
C56H77N17O13

[ Molecular Weight ]:
1196.32000

[ Exact Mass ]:
1195.59000

[ PSA ]:
472.13000

[ LogP ]:
1.49590

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
OK6400000
CHEMICAL NAME :
Luteinizing hormone-releasing hormone, (D-ala(sup 6))-
CAS REGISTRY NUMBER :
51230-19-4
LAST UPDATED :
199506

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>400 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEFTAA Acta Europaea Fertilitatis. (COFESE Eds., Piazzale Ungheria 73, 90141 Palermo, Italy) V.1- 1969- Volume(issue)/page/year: 11,113,1980 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
350 ug/kg
SEX/DURATION :
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - other measures of fertility
REFERENCE :
FESTAS Fertility and Sterility. (American Fertility Soc., 608 13th Ave. S, Birmingham, AL 35282) V.1- 1950- Volume(issue)/page/year: 28,471,1977
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
350 ug/kg
SEX/DURATION :
female 1-7 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
REFERENCE :
EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 6,1,1979
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
3 mg/kg
SEX/DURATION :
female 7-12 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
REFERENCE :
EDRCAM Endocrine Research Communcations. (New York, NY) V.1-9, 1974-83. Volume(issue)/page/year: 6,1,1979

Safety Information

[ Risk Phrases ]:
60

[ Safety Phrases ]:
53-22-36/37/39-45

Related Compounds

  • (Des-Gly10,D-Ala6,Pro-NHEt9)-LHRH acetate salt
  • (D-Ser6,AzaGly10)-LHRH acetate salt
  • (D-2-Nal6)-LHRH acetate salt
  • (D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
  • (Des-Pyr1)-LHRH acetate salt
  • (Glu1,D-Ser(tBu)6,AzaGly10)-LHRH acetate salt
  • 2-[1-(Aminooxy)-4-methylcyclohexyl]acetic acid
  • 2-[1-(Aminooxy)-3,3,5,5-tetramethylcyclohexyl]acetic acid
  • 2-[3-(Aminooxy)thian-3-yl]acetic acid
  • 2-{3,3,5-Trimethyl-1-[(methylamino)oxy]cyclohexyl}acetic acid
  • 3-(3-Chlorophenyl)furan-2-sulfonyl fluoride
  • 4-(3-methoxy-1,2-thiazol-5-yl)-1,3-dimethyl-1H-pyrazol-5-ol
  • methyl 5-(5-hydroxy-1,3-dimethyl-1H-pyrazol-4-yl)-1,2-oxazole-3-carboxylate
  • 4-(5-amino-1,3,4-thiadiazol-2-yl)-1,3-dimethyl-1H-pyrazol-5-ol
  • 4-(3-methoxy-1,2-thiazol-4-yl)-1,3-dimethyl-1H-pyrazol-5-ol
  • 4-bromo-3-(difluoromethyl)-1-methyl-1H-pyrazol-5-ol
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