Tizanidine

Suppliers

Names

[ Name ]:
Tizanidine

[Synonym ]:
5-chloro-N-(4,5-dihydro-1H-imidazol-2-yl)-2,1,3-benzothiadiazol-4-amine
5-chloro-N-(imidazolidin-2-ylidene)-2,1,3-benzothiadiazol-4-amine
Sirdalud
Ternelin
[14C]-Tizanidine
Tizanidina [INN-Spanish]
Zanaflex(R)
Tizanidina
MFCD00798231
Tizanidinum
Zanaflex
UNII-6AI06C00GW
5-chloro-4-(2-imidazolin-2-ylamino)-2,1,3-benzothiadiazole
Tizanidinum [INN-Latin]

Chemical & Physical Properties

[ Density]:
1.82 g/cm3

[ Boiling Point ]:
391.2ºC at 760 mmHg

[ Melting Point ]:
221 - 223ºC

[ Molecular Formula ]:
C₉H₈ClN₅S

[ Molecular Weight ]:
253.71100

[ Flash Point ]:
190.4ºC

[ Exact Mass ]:
253.01900

[ PSA ]:
90.44000

[ LogP ]:
1.55320

[ Storage condition ]:
-20℃

[ Water Solubility ]:
H2O: ~29 mg/mL

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DL0080000

CHEMICAL NAME :: 2,1,3-Benzothiadiazole, 5-chloro-4-(2-imidazolin-2-ylamino)-

CAS REGISTRY NUMBER :: 51322-75-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C9-H8-Cl-N5-S

MOLECULAR WEIGHT :: 253.73

WISWESSER LINE NOTATION :: T56 BNSNJ FM- BT5M CN BUTJ& GG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 600 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - ataxia Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 235 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Behavioral - ataxia Skin and Appendages - hair

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 30,793,1980

Safety Information

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
3

[ RTECS ]:
DK9910000

[ HS Code ]:
2934999090

Customs

[ HS Code ]: 2934999090

[ Summary ]:
2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%