2-Chloro-2',4'-difluoroacetophenone

Names

[ Name ]:
2-Chloro-2',4'-difluoroacetophenone

[Synonym ]:
2',4'-Difluoro-α-chloroacetophenone
2-Chloro-1-(2,4-difluorophenyl)ethanone
MFCD00013252
Ethanone, 2-chloro-1-(2,4-difluorophenyl)-
2,4-Difluorophenacyl Chloride
Voriconazole Impurity 2

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
240.9±25.0 °C at 760 mmHg

[ Melting Point ]:
44-48 °C(lit.)

[ Molecular Formula ]:
C₈H₅ClF₂O

[ Molecular Weight ]:
190.574

[ Flash Point ]:
99.5±23.2 °C

[ Exact Mass ]:
189.999695

[ PSA ]:
17.07000

[ LogP ]:
1.57

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.496

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

MSDS

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45-S25

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
3

[ Packaging Group ]:
II

[ Hazard Class ]:
8

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

DownStream

2',4'-DIFLUORO-2-HYDROXYACETOPHENONE
(R)-2-(2,4-difluoro-phenyl)-3-[1H-1,2,4]triazoll-1-yl-propane-1,2-diol
Posaconazole
Methyl 3-(2,4-difluorophenyl)-3-oxopropanoate
Fluconazole
(S)-2-(TERT-BUTYLAMINO)-1-(2,4-DIFLUOROPHENYL)ETHANOL
1-{[2-(2,4-DIFLUOROPHENYL)OXIRAN-2-YL]METHYL}-1H-1,2,4-TRIAZOLE
2,4-Difluoro-alpha-(1H-1,2,4-triazolyl)acetophenone
1-(2,4-difluorophenyl-2-[1,2,4]triazol-4-yl)ethan-1-one
2-Acetyloxy-1-(2,4-difluorophenyl)ethanone

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, SCH 42538 and SCH 45012.

Bioorg. Med. Chem. Lett. 4(16) , 2023-2028, (1994)

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