2-dimethylamino-1-(1-ethylindol-3-yl)ethanol

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Names

[ CAS No. ]:
5135-83-1

[ Name ]:
2-dimethylamino-1-(1-ethylindol-3-yl)ethanol

[Synonym ]:
1-(1-Aethyl-indol-3-yl)-2-dimethylamino-aethanol
1-(1-ethyl-indol-3-yl)-2-dimethylamino-ethanol

Chemical & Physical Properties

[ Density]:
1.06g/cm3

[ Boiling Point ]:
395.7ºC at 760 mmHg

[ Molecular Formula ]:
C₁₄H₂₀N₂O

[ Molecular Weight ]:
232.32100

[ Flash Point ]:
193.1ºC

[ Exact Mass ]:
232.15800

[ PSA ]:
28.40000

[ LogP ]:
2.25620

[ Index of Refraction ]:
1.559

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NL9485600

CHEMICAL NAME :: Indole-3-methanol, alpha-((dimethylamino)methyl)-1-ethyl-

CAS REGISTRY NUMBER :: 5135-83-1

BEILSTEIN REFERENCE NO. :: 0192669

LAST UPDATED :: 199612

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C14-H20-N2-O

MOLECULAR WEIGHT :: 232.36

WISWESSER LINE NOTATION :: T56 BNJ B2 DYQ1N1&1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 80 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 6,75,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 233 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 6,75,1963

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Vascular - BP lowering not characterized in autonomic section Kidney, Ureter, Bladder - urine volume increased

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 6,75,1963

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FAZMAE Fortschritte der Arzneimittelforschung. Progress in Drug Research. (Birkhauser Boston, Inc., c/o Springer-Verlag New York, 44 Hartz Way, Secaucus, NJ 07094) V.1- 1959- Volume(issue)/page/year: 6,75,1963

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Indole
indole-3-glyoxylyl chloride
1H-Indole-3-acetamide,N,N-dimethyl-α-oxo-

DownStream

Related Compounds

2-(dimethylamino)-1-(1-hexylindol-3-yl)ethanol
U 5092
alpha-((Dimethylamino)methyl)-1-isopropylindole-3-methanol
2-dimethylamino-1-(3-methoxyphenanthren-9-yl)ethanol
SaRI 59-801
ASINEX-REAG BAS 12968509
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(2S)-5-ethoxy-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-oxopentanoic acid
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Tert-butyl 5-amino-2-fluoro-3-methylbenzoate

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