Fludrocortisone acetate

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Names

[ CAS No. ]:
514-36-3

[ Name ]:
Fludrocortisone acetate

[Synonym ]:
9-Fluoro-11-β,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
Corticosterone, 9-fluoro-17-hydroxy-, 21-acetate
fludrocortisone 21-acetate
9-Fluoro-11β,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
Alflorone
Pregn-4-ene-3,20-dione, 9-fluoro-11-β,17,21-trihydroxy-, 21-acetate
Cortisol, 9-fluoro-, 21-acetate
F-Cortef
Fludrocortisone acetate
2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethyl acetate
EINECS 208-180-4
Pregn-4-ene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-, 21-acetate (8CI)
MFCD00864160
acétate de 2-[(8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-10,13-diméthyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tétradécahydro-1H-cyclopenta[a]phénanthrén-17-yl]-2-oxoéthyle
FLORINEF
pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11b)-
2-[(8S,9R,10S,11S,13S,14S,17R)-9-Fluor-11,17-dihydroxy-10,13-dimethyl-3-oxo-2,3,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]-2-oxoethylacetat
(11β)-9-Fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
(11b)-9-fluoro-11,17-dihydroxy-3,20-dioxopregn-4-en-21-yl acetate
Pregn-4-ene-3,20-dione, 21-(acetyloxy)-9-fluoro-11,17-dihydroxy-, (11β)-
Scherofluron
Fludrocortisone (acetate)

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
575.1±50.0 °C at 760 mmHg

[ Melting Point ]:
233-234°C

[ Molecular Formula ]:
C₂₃H₃₁FO₆

[ Molecular Weight ]:
422.487

[ Flash Point ]:
301.6±30.1 °C

[ Exact Mass ]:
422.210480

[ PSA ]:
100.90000

[ LogP ]:
2.32

[ Vapour Pressure ]:
0.0±3.6 mmHg at 25°C

[ Index of Refraction ]:
1.564

[ Storage condition ]:
-20°C Freezer

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TU5050000

CHEMICAL NAME :: Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-, 21-acetate

CAS REGISTRY NUMBER :: 514-36-3

LAST UPDATED :: 199710

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C23-H31-F-O6

MOLECULAR WEIGHT :: 422.54

WISWESSER LINE NOTATION :: L E5 B666 OV MUTJ A1 BF CQ E1 FV1OV1 FQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,666,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 240 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 18,666,1987

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H361

[ Precautionary Statements ]:
P280-P301 + P312 + P330

[ Hazard Codes ]:
Xn: Harmful;

[ Risk Phrases ]:
R63

[ Safety Phrases ]:
S22-S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
TU5050000

[ HS Code ]:
2937229000

Precursor & DownStream

Precursor

Pregn-4-ene-3,20-dione,21-(acetyloxy)-9,11-epoxy-17-hydroxy-, (9b,11b)-
11-Epicortisol
Anecortave Acetate
9-Bromo-11,17,21-trihydroxypregn-4-ene-3,20-dione 21-acetate
21-Acetoxy-17α-hydroxy-11α-methansulfonyloxy-pregn-4-en-3,20-dion
Chloroform
HYDROFLUORIC ACID

DownStream

Predef
9-fluoroprednisolone
fludrocortisone

Customs

[ HS Code ]: 2937229000

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