sulfisomidine

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Names

[ CAS No. ]:
515-64-0

[ Name ]:
sulfisomidine

[Synonym ]:
Solfisomidina
4-amino-N-(2,6-dimethyl-pyrimidin-4-yl)-benzenesulfonamide
Sulfaisodimidinum
4-amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
Sulfaisodimidine
Sulfisomidin
Sulfaisomidine
6-(Sulfanilamido)-2,4-dimethyl-1,3-diazine
sulfisomidine
Sulfadimetine
benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
Sulfuisodimidine
Sulphasomidine
Sulfasomidine
MFCD00010567
4-Amino-N-(2,6-dimethylpyrimidin-4-yl)benzenesulfonamide
Sulfudimetine
EINECS 208-204-3
Sulfamethin
2,6-dimethyl-4-pyrimidinyl sulphanilamide
6-(p-Aminophenylsulfonamido)-2,4-dimethylpyrimidine
Domain

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
480.7±55.0 °C at 760 mmHg

[ Melting Point ]:
245ºC

[ Molecular Formula ]:
C₁₂H₁₄N₄O₂S

[ Molecular Weight ]:
278.330

[ Flash Point ]:
244.5±31.5 °C

[ Exact Mass ]:
278.083740

[ PSA ]:
106.35000

[ LogP ]:
-0.43

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.644

[ Storage condition ]:
0-6°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: WO9270000

CHEMICAL NAME :: Sulfanilamide, N(sup 1)-(2,6-dimethyl-4-pyrimidinyl)-

CAS REGISTRY NUMBER :: 515-64-0

BEILSTEIN REFERENCE NO. :: 0261305

LAST UPDATED :: 199707

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C12-H14-N4-O2-S

MOLECULAR WEIGHT :: 278.36

WISWESSER LINE NOTATION :: T6N CNJ B1 D1 FMSWR DZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 50 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 94,338,1953 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 6 gm/kg

SEX/DURATION :: female 9-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: SEIJBO Senten Ijo. Congenital Anomalies. (Nippon Senten Ijo Gakkai, c/o Kinki Daigaku Igakubu Kaibagaku Kyoshitsu, 380 Nishiyama, Sayama-cho, Mirami-Kawachi-gun, Osaka-fu, Japan) V.1-26, 1960-86. For publisher information, see CGANE7. Volume(issue)/page/year: 13,7,1973

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Unreported

DOSE :: 2500 mg/kg

SEX/DURATION :: female 8-12 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: AKGIAO Akushcherstvo i Ginekologiya (Moscow). (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) No.1- 1936- Volume(issue)/page/year: 43(12),10,1967

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
S26;S36

[ RIDADR ]:
UN 3249

[ RTECS ]:
WO9270000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2935009090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2,6-Dimethyl-4-pyrimidinamine
4-nitro-benzenesulfonic acid-(2,6-dimethyl-pyrimidin-4-ylamide)
nosyl chloride
4-CHLORO-2,6-DIMETHYLPYRIMIDINE
Sulfanilamide
4-Acetamidobenzenesulfonyl chloride
4-acetylamino-N-(4-acetylamino-benzenesulfonyl)-N-(2,6-dimethyl-pyrimidin-4-yl)-benzenesulfonamide
2,4-dimethyl-6-methylsulfanyl-pyrimidine
N-(2,6-dimethyl-pyrimidin-4-yl)-4-nitro-N-(4-nitro-benzensulfonyl)-benzenesulfonamide

DownStream

Customs

[ HS Code ]: 2935009090

[ Summary ]:
2935009090 other sulphonamides VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:35.0%

Articles

Fast determination of 22 sulfonamides from chicken breast muscle using core-shell nanoring amino-functionalized superparamagnetic molecularly imprinted polymer followed by liquid chromatography-tandem mass spectrometry.

J. Chromatogr. A. 1345 , 17-28, (2014)

A novel, simple and sensitive method was developed for the simultaneous determination of 22 sulfonamides (SAs) in chicken breast muscle by using the dispersive micro-solid-phase extraction (d-μ-SPE) p...

Multiresidue analysis of sulfonamides, quinolones, and tetracyclines in animal tissues by ultra-high performance liquid chromatography-tandem mass spectrometry.

Food Chem. 204 , 252-62, (2016)

A multiresidue method for the efficient identification and quantification of 38 compounds from 3 different classes of antibiotics (tetracyclines, sulfonamides, and quinolones) in animal tissues has be...

Coulometric determination of sulphisomidine, sulphamethoxydiazine and sulphamoxole.

J. Pharm. Biomed. Anal. 9(2) , 199-201, (1991)

Sulfisomidine Sodium
N4-acetyl-sulfisomidine
N4-Formyl-sulfisomidine
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3-Chloro-2-(3,3-difluorocyclobutyl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
3-(2,6-Difluorophenyl)-1-(4-methylpyridin-3-yl)urea
3-(5-Fluoropyridin-2-yl)-1-(2-methoxyphenyl)urea
2-[4-(Methylamino)phenyl]acetonitrile hydrochloride
CID 145915289
4-(3-Bromo-1H-1,2,4-triazol-5-YL)morpholine dihydrochloride
(5-Bromo-1H-1,2,4-triazol-3-YL)methanamine dihydrobromide
8-Tert-butyl 3-ethyl 2,8-diazaspiro[4.5]decane-3,8-dicarboxylate hydrochloride
2-(Tert-butoxycarbonyl)-2,8-diazaspiro[4.5]decane-3-carboxylic acid hydrochloride

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