(R)-(-)-Epichlorohydrin
Suppliers
Names
[ CAS No. ]:
51594-55-9
[ Name ]:
(R)-(-)-Epichlorohydrin
[Synonym ]:
EINECS 424-280-2
(2R)-(Chloromethyl)oxirane
(R)-Chloromethyloxirane
EPICHLOROHYDRIN, (-)-
(R)-3-Chloropropylene Oxide
(2R)-(-)-2-(Chloromethyl)oxirane
(2R)-(-)-3-Chloro-1,2-propenoxide
(R)-(-)-Epichlorohydrin
(R)-(−)-Epichlorohydrin
(-)-Epichlorohydrin
MFCD00077759
(R)-Epichlorohydrin
()-Chloromethyl oxirane
(2R)-2-(Chloromethyl)oxirane
Oxirane, 2-(chloromethyl)-, (2R)-
(-)-2-(Chloromethyl)oxirane
T3OTJ B1G &&(R)-(-)- Form
(R)-1-Chloro-2,3-epoxypropane
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
116.1±0.0 °C at 760 mmHg
[ Melting Point ]:
-48ºC
[ Molecular Formula ]:
C3H5ClO
[ Molecular Weight ]:
92.524
[ Flash Point ]:
33.9±0.0 °C
[ Exact Mass ]:
92.002892
[ PSA ]:
12.53000
[ LogP ]:
0.45
[ Vapour Pressure ]:
22.0±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.444
[ Storage condition ]:
2~8°C
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- RR0427000
- CHEMICAL NAME :
- Oxirane, (chloromethyl)-, (R)-
- CAS REGISTRY NUMBER :
- 51594-55-9
- BEILSTEIN REFERENCE NO. :
- 1420785
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C3-H5-Cl-O
- MOLECULAR WEIGHT :
- 92.53
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Mutation test systems - not otherwise specified
- TYPE OF TEST :
- Cytogenetic analysis
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 298,197,1993
Safety Information
[ Symbol ]:
GHS02, GHS05, GHS06, GHS08
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H226-H301-H311-H314-H317-H331-H350
[ Precautionary Statements ]:
P201-P261-P280-P301 + P310-P305 + P351 + P338-P310
[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
T:Toxic
[ Risk Phrases ]:
R10;R23/24/25;R34;R43;R45
[ Safety Phrases ]:
S45-S53
[ RIDADR ]:
UN 2023
[ WGK Germany ]:
3
[ RTECS ]:
RR0427000
[ Packaging Group ]:
II
[ Hazard Class ]:
6.1
[ HS Code ]:
2910900090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2910900090
[ Summary ]:
2910900090. epoxides, epoxyalcohols, epoxyphenols and epoxyethers, with a three-membered ring, and their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%
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A strategy for the enantioselective synthesis of trans-2,4-disubstituted piperidines is proposed and applied to the preparation of IS811, a potent CCR3 antagonist. The C2 stereocenter is derived from ...