6-Aminofluorescein

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Names

[ Name ]:
6-Aminofluorescein

[Synonym ]:
Fluoresceinamine (isomer II)
5-amino-3',6'-dihydroxyspiro[2-benzofuran-3,9'-xanthene]-1-one
6-Amino-3',6'-dihydroxy-3H-spiro[2-benzofuran-1,9'-xanthen]-3-one
6-Amino-3',6'-dihydroxy-3H-spiro[isobenzofuran-1,9'-xanthen]-3-one
Spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, 6-amino-3',6'-dihydroxy-
6-Amino-3',6'-dihydroxyspiro[isobenzofuran-1(3H),9'-(9H)xanthen]-3-one (isomer II)
MFCD00005051
6-Amino-3',6'-dihydroxyspiro(isobenzofuran-1(3H),9'-(9H)xanthene)-3-one
Spiro(isobenzofuran-1(3H),9'-(9H)xanthen)-3-one, 6-amino-3',6'-dihydroxy-
EINECS 257-334-7
Fluoresceinamine isomer II

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
706.7±60.0 °C at 760 mmHg

[ Melting Point ]:
285 °C (dec.)(lit.)

[ Molecular Formula ]:
C₂₀H₁₃NO₅

[ Molecular Weight ]:
347.321

[ Flash Point ]:
381.2±32.9 °C

[ Exact Mass ]:
347.079376

[ PSA ]:
102.01000

[ LogP ]:
2.20

[ Vapour Pressure ]:
0.0±2.3 mmHg at 25°C

[ Index of Refraction ]:
1.820

[ Storage condition ]:
2-8°C

[ Stability ]:
Light and Moisture Sensitive

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Resorcine
6-Nitrofluorescein (isomer II)
4-Nitrophthalic acid
3',6'-Bis(acetyloxy)-6-nitrospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one
N-Methyl-4-aminophthalimide

DownStream

ethyl 4-amino-2-(3-hydroxy-6-oxoxanthen-9-yl)benzoate
Fluorescein isothiocyanate (Spiro Form)

Articles

Preparation of Highly Monodisperse Monopatch Particles with Orthogonal Click-Type Functionalization and Biorecognition.

Small 11 , 4540-8, (2015)

Patchy particles are next generation colloidal building blocks for self-assembly and find further use as (bio) sensors. Progress in this direction crucially depends on developing straightforward prepa...

One-Step Generation of Multifunctional Polyelectrolyte Microcapsules via Nanoscale Interfacial Complexation in Emulsion (NICE).

ACS Nano 9 , 8269-78, (2015)

Polyelectrolyte microcapsules represent versatile stimuli-responsive structures that enable the encapsulation, protection, and release of active agents. Their conventional preparation methods, however...

Shape Effect on Particle-Lipid Bilayer Membrane Association, Cellular Uptake, and Cytotoxicity.

ACS Appl. Mater. Interfaces 7 , 23993-4000, (2015)

Although computer simulation and cell culture experiments have shown that elongated spherical particles can be taken up into cells more efficiently than spherical particles, experimental investigation...

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