COLCHICEINE, N-DEACETYL-N-METHYL-
Suppliers
Names
[ CAS No. ]:
518-11-6
[ Name ]:
COLCHICEINE, N-DEACETYL-N-METHYL-
[Synonym ]:
Demecolcein
(S)-10-hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-one
demecolceine
(7s)-9-hydroxy-1,2,3-trimethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-10(5h)-one
(S)-10-Hydroxy-1,2,3-trimethoxy-7-methylamino-6,7-dihydro-5H-benzo[a]heptalen-9-on
N-Desacetyl-N-methylcolchiceine
Chemical & Physical Properties
[ Density]:
1.27g/cm3
[ Boiling Point ]:
626.4ºC at 760 mmHg
[ Molecular Formula ]:
C20H23NO5
[ Molecular Weight ]:
357.40000
[ Flash Point ]:
332.6ºC
[ Exact Mass ]:
357.15800
[ PSA ]:
77.02000
[ LogP ]:
3.04280
[ Index of Refraction ]:
1.608
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GH0600000
- CHEMICAL NAME :
- Colchiceine, N-deacetyl-N-methyl-
- CAS REGISTRY NUMBER :
- 518-11-6
- LAST UPDATED :
- 198712
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C20-H23-N-O5
- MOLECULAR WEIGHT :
- 357.44
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 50 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - muscle weakness Gastrointestinal - hypermotility, diarrhea
- REFERENCE :
- PHTXA6 Pharmacology and Toxicology. English translation of FATOAO. (New York, NY) V.20-22, 1957-59. Discontinued. Volume(issue)/page/year: 20,284,1957