Acetamide, N- (5,6,7,10-tetrahydro-1,2,3, 9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl)-, (S)-

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Names

[ CAS No. ]:
518-12-7

[ Name ]:
Acetamide, N- (5,6,7,10-tetrahydro-1,2,3, 9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl)-, (S)-

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Molecular Formula ]:
C22H25NO6

[ Molecular Weight ]:
399.43700

[ Exact Mass ]:
399.16800

[ PSA ]:
83.09000

[ LogP ]:
3.26250

[ Index of Refraction ]:
1.592

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AC8750000
CHEMICAL NAME :
Acetamide, N-(5,6,7,10-tetrahydro-1,2,3,9-tetramethoxy-10-oxoben zo(a)heptalen-7-yl)-, (S)-
CAS REGISTRY NUMBER :
518-12-7
BEILSTEIN REFERENCE NO. :
2824880
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C22-H25-N-O6
MOLECULAR WEIGHT :
399.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 33,1606,1950

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (7S)-7-amino-1,2,3,9-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-10-one
  • Ethanoic anhydride
  • (+/-)-N-deacetylcolchiceine
  • N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
  • (R/S)-N-Deacetyl Colchiceine N-Trifluroracetate
  • (+/-)-N-deacetylisocolchicine
  • (+/-)-N-(trifluoroacetyl)deacetylisocolchicine
  • Sodium Methylate
  • 9-demethoxy-9-mesylisocolchicine
  • Colchiceine

DownStream

  • Acetamide,N-[(7S)-9-amino-5,6,7,10-tetrahydro-1,2,3-trimethoxy-10-oxobenzo[a]heptalen-7-yl]-
  • Acetamide,N-[(7S)-9-ethoxy-5,6,7,10-tetrahydro-1,2,3-trimethoxy-10-oxobenzo[a]heptalen-7-yl]-
  • Colchinol, N-acetyl-, methyl ether

Related Compounds

  • 1-(2,5-Dimethylphenyl)-2-(ethylthio)propan-1-one
  • 2-(Ethylthio)-1-(2,4,5-trimethylphenyl)ethan-1-one
  • [4-(7H-Purin-6-yl)morpholin-2-yl]methanamine
  • N-(4-methoxybenzyl)-3-(pyrazin-2-yl)-1,2,4-oxadiazole-5-carboxamide
  • 5-(3,4-dichlorophenyl)-2-(isopropylthio)-1-(3-(trifluoromethyl)phenyl)-1H-imidazole
  • 2-((5-(3,4-dichlorophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)thio)acetamide
  • methyl 6-({[4-(2-fluoro-4-methoxyphenyl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl]carbonyl}amino)hexanoate
  • 2-((5-(3,4-dichlorophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)thio)-N-phenylacetamide
  • 4-[2-[4-(3-Chlorophenyl)-3,6,6-trioxo-4a,5,7,7a-tetrahydro-2H-thieno[3,4-b]pyrazin-1-yl]ethyl]benzenesulfonamide
  • N-(3-chlorophenyl)-2-((5-(3,4-dichlorophenyl)-1-(3-(trifluoromethyl)phenyl)-1H-imidazol-2-yl)thio)acetamide
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