Acetamide, N- (5,6,7,10-tetrahydro-1,2,3, 9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl)-, (S)-

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Names

[ CAS No. ]:
518-12-7

[ Name ]:
Acetamide, N- (5,6,7,10-tetrahydro-1,2,3, 9-tetramethoxy-10-oxobenzo[a]heptalen-7-yl)-, (S)-

Chemical & Physical Properties

[ Density]:
1.31g/cm3

[ Molecular Formula ]:
C₂₂H₂₅NO₆

[ Molecular Weight ]:
399.43700

[ Exact Mass ]:
399.16800

[ PSA ]:
83.09000

[ LogP ]:
3.26250

[ Index of Refraction ]:
1.592

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: AC8750000

CHEMICAL NAME :: Acetamide, N-(5,6,7,10-tetrahydro-1,2,3,9-tetramethoxy-10-oxoben zo(a)heptalen-7-yl)-, (S)-

CAS REGISTRY NUMBER :: 518-12-7

BEILSTEIN REFERENCE NO. :: 2824880

LAST UPDATED :: 199612

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C22-H25-N-O6

MOLECULAR WEIGHT :: 399.48

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD - Lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: HCACAV Helvetica Chimica Acta. (Verlag Helvetica Chimica Acta, Postfach, CH-4002 Basel, Switzerland) V.1- 1918- Volume(issue)/page/year: 33,1606,1950

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

(7S)-7-amino-1,2,3,9-tetramethoxy-6,7-dihydro-5H-benzo[a]heptalen-10-one
Ethanoic anhydride
(+/-)-N-deacetylcolchiceine
N-(1,2,3,10-tetramethoxy-9-oxo-6,7-dihydro-5H-benzo[a]heptalen-7-yl)acetamide
(R/S)-N-Deacetyl Colchiceine N-Trifluroracetate
(+/-)-N-deacetylisocolchicine
(+/-)-N-(trifluoroacetyl)deacetylisocolchicine
Sodium Methylate
9-demethoxy-9-mesylisocolchicine
Colchiceine

DownStream