pyranocoumarin
Suppliers
Names
[ CAS No. ]:
518-20-7
[ Name ]:
pyranocoumarin
[Synonym ]:
Pyranocumarin [German]
Cumopyran
Compound 63 link
CYCLOCUMAROL
Methanopyranorin
Cyclocoumarol
Anticoagulans 63
BL 5
Cumopyrin
Pyranocoumarin
Chemical & Physical Properties
[ Density]:
1.27g/cm3
[ Boiling Point ]:
488.6ºC at 760 mmHg
[ Melting Point ]:
166°
[ Molecular Formula ]:
C20H18O4
[ Molecular Weight ]:
322.35500
[ Flash Point ]:
216.2ºC
[ Exact Mass ]:
322.12100
[ PSA ]:
48.67000
[ LogP ]:
4.07000
[ Index of Refraction ]:
1.624
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UQ0335200
- CHEMICAL NAME :
- 2H,5H-Pyrano(3,2-c)(1)benzopyran-5-one, 3,4-dihydro-2-methoxy-2-methyl-4-phenyl-
- CAS REGISTRY NUMBER :
- 518-20-7
- LAST UPDATED :
- 199409
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C20-H18-O4
- MOLECULAR WEIGHT :
- 322.38
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85ARAE "Agricultural Chemicals," Thomson, W.T., 4 vols., Fresno, CA, Thomson Publications, 1976/77 revision Volume(issue)/page/year: 3,142,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 21 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 85JFAN "Agrochemicals Handbook," with updates, Hartley, D., and H. Kidd, eds., Nottingham, Royal Soc. of Chemistry, 1983-86 Volume(issue)/page/year: A355,1983
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 83,471,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- SMWOAS Schweizerische Medizinische Wochenschrift. (Schwabe & Co., Steintorst 13, 4010 Basel, Switzerland) V.50- 1920- Volume(issue)/page/year: 83,471,1953
Safety Information
[ Symbol ]:
GHS06
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H310
[ Precautionary Statements ]:
P262-P280-P302 + P352 + P310-P361 + P364
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
[ Hazard Codes ]:
T+
[ Risk Phrases ]:
27
[ Safety Phrases ]:
28-36/37-45
[ RIDADR ]:
UN 2811
[ RTECS ]:
UQ0335200
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2932999099
Customs
[ HS Code ]: 2932999099
[ Summary ]:
2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
J. Med. Chem. 27(8) , 1092-5, (1984)
An octanol/water model system and circular dichroism (CD) spectroscopy have been used to study the solution conformation of warfarin in aqueous and lipid environments. Upon partitioning of (S)-warfari...
Arch. Biochem. Biophys. 372(1) , 16-28, (1999)
Possible reasons for the observed differences in metabolic behavior and drug interaction liability between the structurally similar oral anticoagulants warfarin and phenprocoumon were explored. Incuba...
Acta Virol. 37(4) , 241-50, (1993)
A single dose of coumarin derivatives, warfarin, 4-hydroxycoumarin and umbelliferone, added at the time of inoculation either by free virus or by contact with U1 monocytes exhibited a dose-dependent i...