Benzhexol hydrochloride
Suppliers
Names
[ CAS No. ]:
52-49-3
[ Name ]:
Benzhexol hydrochloride
[Synonym ]:
1-(3-cyclohexyl-3-hydroxy-3-phenylpropyl)piperidinium chloride
1-Cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-olhydrochlorid
Trihexy
1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride (1:1)
UNII:AO61G82577
1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-olhydrochlorid
1-cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol hydrochloride
1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride (1:1)
pacitane
Broflex
(-)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride
1-cyclohexyl-1-phenyl-3-piperidin-1-ylpropan-1-ol hydrochloride
pipanol
1-Cyclohexyl-1-phenyl-3-(1-piperidinyl)-1-propanol hydrochloride (1:1)
1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride, (+)-
tremin
EINECS 205-614-4
Benzhexol HCL
Parkan
paralest
peragit
Sedrina
(+)-α-Cyclohexyl-α-phenyl-1-piperidinepropanol hydrochloride
cyclodol
a-Cyclohexyl-a-phenyl-1-piperidinepropanol Hydrochloride
MFCD00058212
trihexylphenidyl HCl
1-Cyclohexyl-1-phenyl-3-(piperidin-1-yl)propan-1-ol hydrochloride
1-cyclohexyl-1-phényl-3-pipéridin-1-ylpropan-1-ol chlorhydrate
D,L-Trihexyphenidyl Hydrochloride
1-Piperidinepropanol, α-cyclohexyl-α-phenyl-, hydrochloride, (-)-
Trihexyphenidyl hydrochloride
Chemical & Physical Properties
[ Boiling Point ]:
447.9ºC at 760mmHg
[ Melting Point ]:
258.5ºC
[ Molecular Formula ]:
C20H32ClNO
[ Molecular Weight ]:
337.927
[ Flash Point ]:
211ºC
[ Exact Mass ]:
337.217255
[ PSA ]:
23.47000
[ LogP ]:
5.07040
[ Appearance of Characters ]:
solid | white
[ Water Solubility ]:
H2O: soluble
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- TN2625000
- CHEMICAL NAME :
- 1-Piperidinepropanol, alpha-cyclohexyl-alpha-phenyl-, hydrochloride
- CAS REGISTRY NUMBER :
- 52-49-3
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 11
- MOLECULAR FORMULA :
- C20-H31-N-O.Cl-H
- MOLECULAR WEIGHT :
- 337.98
- WISWESSER LINE NOTATION :
- T6NTJ A2XQR&- AL6TJ &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - woman
- DOSE/DURATION :
- 800 ug/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Behavioral - toxic psychosis
- REFERENCE :
- BJPYAJ British Journal of Psychiatry. (Headley Brothers, Ltd., Ashford, Kent TN24 8HH, UK) V.109- 1963- Volume(issue)/page/year: 145,300,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 400 ug/kg/1W-I
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified
- REFERENCE :
- NEURAI Neurology. (Modern Medicine Pub., Inc., 1 E. First St., Duluth, MN 55802) V.1- 1951- Volume(issue)/page/year: 37,832,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1630 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Behavioral - excitement
- REFERENCE :
- TOVEFN Toksikologicheskii Vestnik. (18-20 Vadkovskii per. Moscow, 101479, Russia) History Unknown Volume(issue)/page/year: (4),40,1994
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 195 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 30 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 217 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,525,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 150 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 37,483,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 152 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 39 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,311,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - parasympatholytic
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 137,375,1962 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5568 No. of Facilities: 59 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 2666 (estimated) No. of Female Employees: 1339 (estimated)
Safety Information
[ Hazard Codes ]:
Xn
[ Risk Phrases ]:
R22
[ Safety Phrases ]:
S36
[ RIDADR ]:
3249
[ WGK Germany ]:
3
[ RTECS ]:
TN2625000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933990090
Customs
[ HS Code ]: 2933399090
[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
Articles
BMJ Case Rep. 2013 , doi:10.1136/bcr-2012-007577, (2013)
The patient is a 52-year-old man with schizophrenia who developed severe, unremitting gingival pain after his ziprasidone dosage was increased from 80 to 120 mg. His physical examination and laborator...
BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012)
J. Neurol. Neurosurg. Psychiatr. 83(10) , 1012-4, (2012)
DYT16 is an autosomal recessive dystonia-parkinsonism due to putative mutations at PRKRA gene. The aim of this study was to describe clinical features providing video documentation of patients with DY...