Mebendazole-amine

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Names

[ Name ]:
Mebendazole-amine

[Synonym ]:
Ketone,2-amino-5-benzimidazolyl phenyl
G-1029
Benzimidazole,2-amino-5-benzoyl
2-Amino-5-benzoyl-1H-benzimidazole
2-Amino-5-benzoylbenzimidazole
KETONE,2-AMINO-6-BENZIMIDAZOLYL PHENYL

Chemical & Physical Properties

[ Density]:
1.351g/cm3

[ Boiling Point ]:
504.5ºC at 760 mmHg

[ Melting Point ]:
176-185°C

[ Molecular Formula ]:
C₁₄H₁₁N₃O

[ Molecular Weight ]:
237.25700

[ Flash Point ]:
258.9ºC

[ Exact Mass ]:
237.09000

[ PSA ]:
72.50000

[ LogP ]:
2.30620

[ Index of Refraction ]:
1.738

[ Storage condition ]:
-20°C Freezer, Under Inert Atmosphere

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OB1085000

CHEMICAL NAME :: Ketone, 2-amino-6-benzimidazolyl phenyl

CAS REGISTRY NUMBER :: 52329-60-9

LAST UPDATED :: 199307

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C14-H11-N3-O

MOLECULAR WEIGHT :: 237.28

WISWESSER LINE NOTATION :: T56 BM DNJ CZ GVR

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 450 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 257 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: MPPBAB Meditsinskaya Parazitologiya i Parazitarnye Bolezni. Medical Parasitology and Parasitic Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1932- Volume(issue)/page/year: 48(4),29,1979 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 755 mg/kg

SEX/DURATION :: female 8-15 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Effects on Embryo or Fetus - fetal death

REFERENCE :: THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 31,505,1976

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Precautionary Statements ]:
P301 + P312 + P330

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
OB1085000

[ HS Code ]:
2933990090

Precursor & DownStream

Precursor

DownStream

methyl 2-amino-6-benzoyl-1H-benzo[d]imidazole-1-carboxylate
Mebendazole
2-Amino-5(6)-[α-hydroxybenzyl]benzimidazole
1-(6-benzoyl-1H-benzimidazol-2-yl)-3-(4-nitrophenyl)urea
2-amino-6-benzoyl-1-[(isopropyl)sulphonyl]-1H-benzimidazole

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

trimethyl-amine oxide, hydriodide
1-Amine-1-carba-closo-dodecaborane(11)
CYTOXYL AMINE
(METHYLSULFAMOYL)AMINE
N-amine-4-methylpyridinium mesitylenesulfonate
dimethyl-amine, compound with boron chloride
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
2-(1,3-Benzothiazol-2-yl)-2-methoxypropan-1-amine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide