1,2-NAPHTHOQUINONE

Names

[ CAS No. ]:
524-42-5

[ Name ]:
1,2-NAPHTHOQUINONE

[Synonym ]:
EINECS 208-360-2
1,2-Naphthalenedione
MFCD00001698
1,2-NAPHTHOQUINONE

Chemical & Physical Properties

[ Density]:
1.29g/cm3

[ Melting Point ]:
139-142 °C (dec.)(lit.)

[ Molecular Formula ]:
C₁₀H₆O₂

[ Molecular Weight ]:
158.15300

[ Flash Point ]:
117.4ºC

[ Exact Mass ]:
158.03700

[ PSA ]:
34.14000

[ LogP ]:
1.46520

[ Index of Refraction ]:
1.617

[ Storage condition ]:
2-8°C

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: QL7000000

CHEMICAL NAME :: 1,2-Naphthoquinone

CAS REGISTRY NUMBER :: 524-42-5

BEILSTEIN REFERENCE NO. :: 0606546

LAST UPDATED :: 199701

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C10-H6-O2

MOLECULAR WEIGHT :: 158.16

WISWESSER LINE NOTATION :: L66 BVVJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,39,1953

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Bird - wild bird species

DOSE/DURATION :: 75 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 12,355,1983

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn,Xi,C,F

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
QL7000000

[ HS Code ]:
2914690090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

benzocatechol
1-Naphthalenol
5-hydroxy-6-methoxynaphthalene
1-Amino-2-naphthol
2-Naphthol
3,4-Dihydronaphthalen-1(2H)-one
[(hydroxy-2' naphthyl)-1]-3 methylene-2 propionate d'ethyle
Naphthalene
1-Bromo-2-naphthol
2-Hydroxy-naphthaldehyde

DownStream

1H-Inden-1-one
2-Nitro-1-naphthol
Benz(a)anthracene
3,4-Dibromo-1,2-naphthoquinone
3-chloronaphthalene-1,2-dione
2-Hydroxy-1,4-naphoquinone
benzocatechol
1H-2-Benzopyran-1-one

Customs

[ HS Code ]: 2914690090

[ Summary ]:
2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%

Articles

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

A new method and tool for detection and quantification of PM oxidative potential.

Environ. Sci. Pollut. Res. Int. 22 , 12469-78, (2015)

Airborne particulate matter (PM) contains several quinones, which are able to generate reactive oxygen species impacting on cell viability. A method able to detect and quantify PM oxidative potential,...

Indoleamine 2,3-dioxygenase is the anticancer target for a novel series of potent naphthoquinone-based inhibitors.

J. Med. Chem. 51 , 1706-18, (2008)

Indoleamine 2,3-dioxygenase (IDO) is emerging as an important new therapeutic target for the treatment of cancer, chronic viral infections, and other diseases characterized by pathological immune supp...