2-Methylbenzamide

Names

[ CAS No. ]:
527-85-5

[ Name ]:
2-Methylbenzamide

[Synonym ]:
o-Toluene amide
o-Toluic amide
o-tolylamide
Formyl-o-toluidine
2-Me-Ph-CO-NH2
2-TOLUAMIDE
2-methyl-benzamid
2-METHYLBENZAMIDE
o-Methylbenzamide

Chemical & Physical Properties

[ Density]:
1.086 g/cm3

[ Boiling Point ]:
254.3ºC at 760 mmHg

[ Melting Point ]:
141-142ºC(lit.)

[ Molecular Formula ]:
C₈H₉NO

[ Molecular Weight ]:
135.16300

[ Flash Point ]:
107.6ºC

[ Exact Mass ]:
135.06800

[ PSA ]:
43.09000

[ LogP ]:
1.79420

[ Index of Refraction ]:
1.556

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4-Iodotoluene
carbon monoxide
o-Tolunitrile
2-Bromotoluene
O-Toluoylchloride
2-Methylbenzaldehyde
2-Methylbenzyl Alcohol
2-Methylacetophenone
Adenosine
4-METHYL-N-(2-METHYL-BENZOYL)-BENZENESULFONAMIDE

DownStream

2-methyl-benzenemethanaminhydrochloride
2-Methylbenzyl Alcohol
o-Xylylamine
o-Toluidine
Ethyl 2-methylbenzoate
o-Tolunitrile
1-Isocyanato-2-methylbenzene
2-Methylbenzothioamide
2-Methylcyclohexa-2,5-diene-1,4-dione

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

First total synthesis of the phenolic 7,8-dihydro-8-oxoprotoberberine alkaloid, cerasonine.

Chem. Pharm. Bull. 56(7) , 1026-9, (2008)

First total synthesis of the phenolic protoberberine, cerasonine, was accomplished through a coupling reaction between o-toluamide and benzonitrile. This key step provided the 3-arylisoquinoline which...