6,7-Dihydroxy-4-methyl-2H-chromen-2-one

Suppliers

Names

[ CAS No. ]:
529-84-0

[ Name ]:
6,7-Dihydroxy-4-methyl-2H-chromen-2-one

[Synonym ]:
6,7-Dihydroxy-4-methylcoumarin
4-Methylesculetin
EINECS 208-470-0
MFCD00006859
6,7-Dihydroxy-4-methyl-2H-chromen-2-one
2H-1-Benzopyran-2-one, 6,7-dihydroxy-4-methyl-
6,7-dihydroxy-4-methylchromen-2-one

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
455.5±45.0 °C at 760 mmHg

[ Melting Point ]:
274-276 °C(lit.)

[ Molecular Formula ]:
C10H8O4

[ Molecular Weight ]:
192.168

[ Flash Point ]:
190.8±22.2 °C

[ Exact Mass ]:
192.042252

[ PSA ]:
70.67000

[ LogP ]:
2.08

[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C

[ Index of Refraction ]:
1.652

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMF: soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GN6384500
CHEMICAL NAME :
Coumarin, 6,7-dihydroxy-4-methyl-
CAS REGISTRY NUMBER :
529-84-0
BEILSTEIN REFERENCE NO. :
0162550
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C10-H8-O4
MOLECULAR WEIGHT :
192.18

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5130 mg/kg
TOXIC EFFECTS :
Cardiac - arrhythmias (including changes in conduction) Cardiac - cardiomegaly Nutritional and Gross Metabolic - body temperature decrease
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 20,879,1965
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
3200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MPHEAE Medicina et Pharmacologia Experimentalis. (Basel, Switzerland) V.12-17, 1965-67. For publisher information, see PHMGBN. Volume(issue)/page/year: 17,497,1967

Safety Information

[ Hazard Codes ]:
Xi: Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ WGK Germany ]:
2

[ RTECS ]:
GN6384500

[ HS Code ]:
2932209090

Precursor & DownStream

Precursor

  • 1,2,4-Trihydroxybenzene
  • Ethyl acetoacetate
  • 1,2,4-Triacetoxybenzene
  • 4-methyl-2-oxo-2H-chromene-6,7-diyl bis(4-oxopentanoate)
  • 6,7-Dihydroxycoumarin
  • Dimethyl sulfoxide
  • 6-Hydroxy-7-methoxy-4-methyl-2H-chromen-2-one
  • 7-Methoxy-4-methylcoumarin
  • 4-Methylumbelliferone
  • Diketene

DownStream

  • 6,7-DIACETOXY-4-METHYLCOUMARIN
  • 6,7-Dimethoxy-4-methylcoumarin
  • 2H-1-Benzopyran-2-one, 7-hydroxy-6-methoxy-4-methyl-
  • 6-Hydroxy-7-methoxy-4-methyl-2H-chromen-2-one
  • 9-methyl-2,3-dihydropyrano[2,3-g][1,4]benzodioxin-7-one
  • 4-METHYL-6,7-BIS(SULFOXY)-2H-1-BENZOPYRAN-2-ONE DISODIUM SALT TRIHYDRATE

Customs

[ HS Code ]: 2932209090

[ Summary ]:
2932209090. other lactones. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 3-Benzyl-6,7-dihydroxy-4-methyl-2H-chromen-2-one
  • 3-Chloro-6,7-dihydroxy-4-methyl-2H-chromen-2-one
  • 3,8-dibromo-6,7-dihydroxy-4-methyl-2H-chromen-2-one
  • 3-Benzyl-5,7-dihydroxy-4-methyl-2H-chromen-2-one
  • 3-Chloro-5,7-dihydroxy-4-methyl-2H-chromen-2-one
  • 3-anilino-4-chloro-1-(4-ethylphenyl)pyrrole-2,5-dione
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 3-Amino-N-[2-(trifluoromethoxy)phenyl]propanamide
  • 2-(3-methoxyphenoxy)-N-[1-(thiophene-2-sulfonyl)-1,2,3,4-tetrahydroquinolin-6-yl]acetamide
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • 2-[(2,6-Dimethylphenyl)methoxy]-3-methoxybenzoic acid