Androsterone

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Names

[ CAS No. ]:
53-41-8

[ Name ]:
Androsterone

[Synonym ]:
3-α-hydroxy-5α-Androstan-17-one
MFCD01317504
Androkinine
5a-Androsterone
Androkinin
Androtine
3alpha-Hydroxy-5alpha-androstan-17-one
Atromide ICI
3-Epihydroxyetioallocholan-17-one
(3a,5a)-3-Hydroxyandrostan-17-one
(3α,5α)-3-Hydroxyandrostan-17-one
(3R,5S,8R,9S,10S,13S,14S)-3-hydroxy-10,13-dimethyl-1,2,3,4,5,6,7,8,9,11,12,14,15,16-tetradecahydrocyclopenta[a]phenanthren-17-one
3α-hydroxy-5α-androstane-17-one
Androtin
3alpha-Hydroxyetioallocholan-17-one
Androstan-3a-ol-17-one
5alpha-Androsterone
3a-Hydroxyetioallocholan-17-one
5alpha-Androstane-3alpha-ol-17-one
Androsterone
trans-Androsterone
Androstan-17-one, 3-hydroxy-, (3α,5α)-
EINECS 200-173-4
Androsterone, trans-
Atromide
(3α,5α)-3-hydroxy-Androstan-17-one
3a-Hydroxy-5a-androstan-17-one

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
413.1±45.0 °C at 760 mmHg

[ Melting Point ]:
180-185ºC

[ Molecular Formula ]:
C19H30O2

[ Molecular Weight ]:
290.440

[ Flash Point ]:
176.4±21.3 °C

[ Exact Mass ]:
290.224579

[ PSA ]:
37.30000

[ LogP ]:
3.75

[ Vapour Pressure ]:
0.0±2.2 mmHg at 25°C

[ Index of Refraction ]:
1.536

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BV8053000
CHEMICAL NAME :
5-alpha-Androstan-17-one, 3-alpha-hydroxy-
CAS REGISTRY NUMBER :
53-41-8
BEILSTEIN REFERENCE NO. :
2217626
LAST UPDATED :
199612
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C19-H30-O2
MOLECULAR WEIGHT :
290.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
8400 ug/kg
SEX/DURATION :
male 21 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 21,313,1937
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intramuscular
DOSE :
80 mg/kg
SEX/DURATION :
female 13-20 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - urogenital system
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 99,1490,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X3818 No. of Facilities: 53 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 767 (estimated) No. of Female Employees: 347 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H319-H334-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338-P342 + P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38-43

[ Safety Phrases ]:
22-24/25

[ RIDADR ]:
2811.0

[ WGK Germany ]:
3

[ RTECS ]:
BV8053000

[ Hazard Class ]:
6.1

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5a-Androstanedione
  • Epiandrosterone acetate
  • (3R,5S,8R,9S,10S,13S,14S)-10,13-dimethyl-3-((tetrahydrofuran-2-yl)oxy)tetradecahydro-1H-cyclopenta[a]phenanthren-17(2H)-one
  • 5a-Androstane-3a,17b-diol
  • 3β-(4-methylphenylsulfonyloxy)-5α-androstan-17-one
  • (3β,5α)-3-hydroxyandrostan-17-one 1,2-ethanediyl acetal
  • Epiandrosterone
  • Androst-5-en-17-one,3-chloro-, (3b)-
  • Testosterone

DownStream

  • 5α-Androst-2-en-17-one
  • (5S,8R,9S,10S,13S,14S)-10,13-dimethyl-1,2,5,6,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthren-17-one
  • androsterone sulfate sodium crystalline
  • Epiandrosterone
  • 5a-Androstanedione
  • 5a-Androstane-3a,17b-diol
  • androsterone 3-glucosiduronic acid
  • 1α,3β-Dihydroxy-5α-androstan-17-on

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Related Compounds

  • androsterone
  • androsterone
  • androsterone
  • androsterone
  • 3b-Androsterone
  • d4-Androsterone
  • 1,4-Bis(3-ethyl-4-methoxybenzenesulfonyl)-1,4-diazepane
  • 1,4-Bis[(5-ethyl-2-methoxyphenyl)sulfonyl]-1,4-diazepane
  • 1,4-Bis(3-tert-butyl-4-methoxybenzenesulfonyl)-1,4-diazepane
  • 1,4-Bis(5-tert-butyl-2-methoxybenzenesulfonyl)-1,4-diazepane
  • 1,4-Bis(3-tert-butyl-4-ethoxybenzenesulfonyl)-1,4-diazepane
  • 1,4-Bis(3-tert-butyl-4-ethoxybenzenesulfonyl)-2-methylpiperazine
  • 1,4-Bis[(4-ethoxy-3-methylphenyl)sulfonyl]-2-methylpiperazine
  • 1,4-Bis[(5-ethyl-2-methoxyphenyl)sulfonyl]-2-methylpiperazine
  • 2-{[3,5-Bis(trifluoromethyl)phenyl]sulfonyl}-1,2,3,4-tetrahydroisoquinoline
  • 2-((3-(Tert-butyl)-4-methoxyphenyl)sulfonyl)-1,2,3,4-tetrahydroisoquinoline
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