Azure A chloride

Suppliers

Names

[ CAS No. ]:
531-53-3

[ Name ]:
Azure A chloride

[Synonym ]:
EINECS 208-510-7
7-(Dimethylamino)-3-imino-3H-phenothiazine Hydrochloride
Methyleneazure
7-Amino-N,N-dimethyl-3H-phenothiazin-3-iminium chloride
N,N,N'-Trimethylthionin
AZURE A, CERTIFIED, PURE
Azure AC.I. 52005
Methanaminium, N-(7-amino-3H-phenothiazin-3-ylidene)-N-methyl-, chloride (1:1)
MFCD00012112
Azure A chloride

Chemical & Physical Properties

[ Boiling Point ]:
442.8ºC at 760 mmHg

[ Melting Point ]:
290 °C (dec.)(lit.)

[ Molecular Formula ]:
C14H14ClN3S

[ Molecular Weight ]:
291.80

[ Flash Point ]:
221.6ºC

[ Exact Mass ]:
291.059692

[ PSA ]:
70.16000

[ Stability ]:
Stable. Incompatible with strong oxidizing agents.

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SP5660000
CHEMICAL NAME :
Phenothiazin-5-ium, 3-amino-7-(dimethylamino)-, chloride
CAS REGISTRY NUMBER :
531-53-3
LAST UPDATED :
199709
DATA ITEMS CITED :
7
MOLECULAR FORMULA :
C14-H14-N3-S.Cl
MOLECULAR WEIGHT :
291.82
WISWESSER LINE NOTATION :
T C666 BN ISJ FZ MN1&1 &G &12/25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
37720 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
59040 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
19340 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory stimulation Lungs, Thorax, or Respiration - other changes

MUTATION DATA

TYPE OF TEST :
Cytogenetic analysis
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
20 umol/L/5H (Continuous)
REFERENCE :
ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 1,27,1979 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M3031 No. of Facilities: 451 (estimated) No. of Industries: 4 No. of Occupations: 3 No. of Employees: 2020 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M3031 No. of Facilities: 661 (estimated) No. of Industries: 2 No. of Occupations: 5 No. of Employees: 5132 (estimated) No. of Female Employees: 2765 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
SP5660000

[ HS Code ]:
2934300000

Synthetic Route

Precursor & DownStream

Precursor

  • methylene blue
  • Methylene Blue cation
  • Dimethylamine

DownStream

Customs

[ HS Code ]: 2934300000

[ Summary ]:
2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

Filamin-interacting proteins, Cfm1 and Cfm2, are essential for the formation of cartilaginous skeletal elements.

Hum. Mol. Genet. 23(11) , 2953-67, (2014)

Mutations of Filamin genes, which encode actin-binding proteins, cause a wide range of congenital developmental malformations in humans, mainly skeletal abnormalities. However, the molecular mechanism...

Ligand polarizability contributes to tau fibril binding affinity.

Bioorg. Med. Chem. 19 , 5147-54, (2011)

Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer's disease. Diverse compounds with high affinity for tau aggrega...


More Articles


Related Compounds

  • azure A chloride
  • Azure A
  • Riccionidin A chloride
  • nile blue A chloride
  • 3-Amino-7-(methylamino)phenothiazin-5-ium chloride
  • azure b