Anethole trithione

Suppliers

Names

[ CAS No. ]:
532-11-6

[ Name ]:
Anethole trithione

[Synonym ]:
Anethole trithione
Halpen
(p-Methoxyphenyl)trithiopropene
EINECS 208-528-5
5-(p-Methoxyphenyl)-1,2-dithiacyclopent-4-ene-3-thione
Anetholetrithion
3-(p-Methoxyphenyl)-4,5-dithiacyclopent-2-ene-1-thione
Tiotrifar
3-(p-Anisyl)trithione
MFCD00129751
Sulfarlem
3H-1,2-Dithiole-3-thione, 5-(4-methoxyphenyl)-
Trithio
Trithio-p-methoxyphenylpropene
Mucinol
Heporal
3-(p-Anisyl)-4,5-dithiacyclopent-2-ene-1-thione
Tiopropen
5-(4-Methoxyphenyl)-3H-1,2-dithiole-3-thione
Sufralem
anetholtrithion
Felviten
Anethole (trithione)

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
398.1±52.0 °C at 760 mmHg

[ Melting Point ]:
23 C

[ Molecular Formula ]:
C10H8OS3

[ Molecular Weight ]:
240.365

[ Flash Point ]:
194.6±30.7 °C

[ Exact Mass ]:
239.973724

[ PSA ]:
105.50000

[ LogP ]:
3.39

[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C

[ Index of Refraction ]:
1.732

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
JP1292500
CHEMICAL NAME :
3H-1,2-Dithiole-3-thione, 5-(p-methoxyphenyl)-
CAS REGISTRY NUMBER :
532-11-6
BEILSTEIN REFERENCE NO. :
0158393
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C10-H8-O-S3
MOLECULAR WEIGHT :
240.36
WISWESSER LINE NOTATION :
T5SSYTJ CUS ER DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 25,815,1994
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intramuscular
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
35 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AEPPAE Naunyn-Schmiedeberg's Archiv fuer Experimentelle Pathologie und Pharmakologie. (Berlin, Ger.) V.110-253, 1925-66. For publisher information, see NSAPCC. Volume(issue)/page/year: 222,244,1954
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1480 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,38,1990
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1780 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,25,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
6 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,25,1982 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
8640 mg/kg/24W-I
TOXIC EFFECTS :
Liver - changes in liver weight Endocrine - changes in adrenal weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)
REFERENCE :
OYYAA2 Oyo Yakuri. Pharmacometrics. (Oyo Yakuri Kenkyukai, CPO Box 180, Sendai 980-91, Japan) V.1- 1967- Volume(issue)/page/year: 12,79,1976

Safety Information

[ Hazard Codes ]:
Xi

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • cis-Anethol
  • trans-Anethole
  • Carbon disulphide
  • Acetanisole
  • (Z)-anethol
  • Estragole
  • 5-(p-methoxyphenyl)dithia[1,2]cyclopenten-3-one
  • 3,3-dimercapto-1-(4-methoxy-phenyl)-propenone

DownStream

  • Desmethylanethol trithione
  • 3-(4-METHOXYPHENYL)-1-PHENYL-1H-PYRAZOL-5-AMINE
  • Phenylhydrazine
  • Benzene, 1,1-(1,2-ethynediyl)bis(4-chloro-
  • 4,5-Bis(4-chlorphenyl)-3H-1,2-dithiol-3-on
  • 3H-1,2-Dithiole-3-thione,4,5-diphenyl-
  • 1-methoxy-4-[6-(4-methoxyphenyl)hexyl]benzene

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 4-Hydroxyanethole trithione
  • trans-Anethole
  • cis-Anethol
  • p-propenylanisole
  • (Z)-anethol
  • 2-(4-methoxyphenyl)-3-methyloxirane
  • 3-Pyridinecarboxylic acid,2-[(ethoxycarbonyl)amino]-4,6-dimethyl-,ethyl ester
  • 3-Pyridinecarboxylic acid,5-bromo-6-chloro-,4-chlorophenyl ester
  • 3-Quinolinecarboxylic acid,5-bromo-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-,ethyl ester
  • 3-Quinolinecarboxylic acid,5-chloro-1-cyclopropyl-6,7-difluoro-1,4-dihydro-4-oxo-,ethyl ester
  • 3-Quinolinecarboxylic acid,8-[2-(acetyloxy)ethyl]-4-chloro-6,7-difluoro-,ethyl ester
  • 4(1h)-Quinolinone,1-cyclopropyl-6,7,8-trifluoro-3-(phenylmethyl)-
  • 4-(2-Chloroacetamido)-n-(3-(trifluoromethyl)phenyl)benzamide
  • 4(3h)-Quinazolinone,2-methyl-3-(2-methylphenyl)-6-nitro-
  • 4(3h)-Quinazolinone,3-(cyclohexylmethyl)-
  • 4h-1-Benzopyran-4-one,2-(3,3-dimethyl-2-oxobutyl)-3-(methoxymethyl)-6-methyl-