Sodium Benzoate

Names

[ CAS No. ]:
532-32-1

[ Name ]:
Sodium Benzoate

[Synonym ]:
EINECS 208-534-8
Butyryl chloride
Benzoic acid,sodium salt
sodium,benzoate
MFCD00012463
Benzoic acid sodium salt
SodiuM Benzoate

Chemical & Physical Properties

[ Density]:
1,44 g/cm3

[ Boiling Point ]:
249.3ºC at 760 mmHg

[ Melting Point ]:
>300 °C(lit.)

[ Molecular Formula ]:
C₇H₅NaO₂

[ Molecular Weight ]:
144.10

[ Flash Point ]:
111.4ºC

[ Exact Mass ]:
144.018723

[ PSA ]:
40.13000

[ LogP ]:
0.05010

[ Stability ]:
Stable, but may be moisture senstive. Incompatible with strong oxidizing agents, alkalis, mineral acids.

[ Water Solubility ]:
soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH6650000

CHEMICAL NAME :: Benzoic acid, sodium salt

CAS REGISTRY NUMBER :: 532-32-1

LAST UPDATED :: 199710

DATA ITEMS CITED :: 30

MOLECULAR FORMULA :: C7-H5-O2.Na

MOLECULAR WEIGHT :: 144.11

WISWESSER LINE NOTATION :: QVR &-NA-

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4070 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1714 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - dyspnea

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1440 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intramuscular

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 2306 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 27370 mg/kg/10D-C

TOXIC EFFECTS :: Liver - changes in liver weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - other proteins

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 84 gm/kg/28D-C

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Kidney, Ureter, Bladder - other changes Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 137 gm/kg/13W-C

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 gm/kg/10D-C

TOXIC EFFECTS :: Liver - changes in liver weight Kidney, Ureter, Bladder - changes in bladder weight Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 44 gm/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - homeostasis Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - musculoskeletal system

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 44 gm/kg

SEX/DURATION :: female 1-22 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Newborn - viability index (e.g., # alive at day 4 per # born alive)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 3 gm/kg

SEX/DURATION :: female 12-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 300 mg/kg

SEX/DURATION :: female 12-14 day(s) after conception

TOXIC EFFECTS :: Reproductive - Effects on Embryo or Fetus - fetal death

MUTATION DATA

TYPE OF TEST :: Cytogenetic analysis

TEST SYSTEM :: Rodent - hamster Fibroblast

DOSE/DURATION :: 2 gm/L/48H

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 48,337,1977 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80214 No. of Facilities: 13289 (estimated) No. of Industries: 84 No. of Occupations: 69 No. of Employees: 92390 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1192 No. of Facilities: 31 (estimated) No. of Industries: 2 No. of Occupations: 2 No. of Employees: 430 (estimated) No. of Female Employees: 288 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80214 No. of Facilities: 20457 (estimated) No. of Industries: 143 No. of Occupations: 125 No. of Employees: 533161 (estimated) No. of Female Employees: 199915 (estimated)

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H319

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xi:Irritant

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
1

[ RTECS ]:
DH6650000

[ HS Code ]:
4002191900

Precursor & DownStream

Precursor

DownStream

silicon benzoate
Iodobenzene
benzoic acid,3-methylpent-1-yn-1-ol
(2-nitrophenyl)methyl benzoate
benzoic acid,3,3-dimethylbut-1-yn-1-ol
benzoic acid,2,2-diethoxyethanol
Methyl benzoate
1-butylimidazole
n-Butyl benzoate
Glycerol, tribenzoate

Customs

[ HS Code ]: 2916310090

[ Summary ]:
2916310090 other benzoic acid and its salts and esters。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%

Articles

Antibacterial activity of fluoride compounds and herbal toothpastes on Streptococcus mutans: an in vitro study.

Aust. Dent. J. 60 , 368-74, (2015)

Streptococcus mutans is an important bacterial species implicated in dental caries. This laboratory study compared the antimicrobial activity of a number of fluoride containing and herbal dentifrices ...

Role of type I & type II radicals in DNA damage and activation of Caspase 3 via mitochondrial pathway induced by photosensitized benzophenone

Toxicol. Lett. 235(2) , 84-95, (2015)

[Display omitted]

Novel UV-spectrophotometric method for quantitative estimation of furazolidone using mixed hydrotropic agent.

Pak. J. Pharm. Sci. 26(1) , 159-62, (2013)

A novel, eco friendly, accurate, sensitive, economic and safe spectrophotometric method was developed by application of mixed hydrotropy using 2 M sodium acetate, 8 M urea, 2 M niacinamide and 2 M sod...

sodium benzoate
Sodium benzoate-d5
Sodium benzoate-3,4,5-d3
m-chloro-sodium benzoate
caffeine-sodium benzoate
p-chloro-sodium benzoate
2,2-difluoro-1-(5-methoxy-1,3-dimethyl-1H-pyrazol-4-yl)cyclopropane-1-carboxylic acid
2-(1-Ethynylcyclopropyl)-4-nitrophenol
Methyl 3-(2-tert-butylphenyl)-2-hydroxypropanoate
3-(2-Cyclopropyl-1,3-thiazol-4-yl)-1,2-oxazol-5-amine
1-(1,2,3,4-Tetrahydronaphthalen-1-yl)cyclopentane-1-carboxylic acid
(2R)-2-amino-2-{pyrazolo[1,5-a]pyridin-3-yl}ethan-1-ol
4-Iodo-2-nitrobenzene-1-sulfonyl fluoride
5-[2-Fluoro-3-(trifluoromethyl)phenyl]-1,3-oxazol-2-amine
2-Methoxy-2-{pyrazolo[1,5-a]pyridin-3-yl}propan-1-amine
1-(2-{[(Tert-butoxy)carbonyl]amino}-4-methyl-1,3-thiazol-5-yl)cyclopentane-1-carboxylic acid

The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.