MEFLOQUINE

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Names

[ CAS No. ]:
53230-10-7

[ Name ]:
MEFLOQUINE

[Synonym ]:
Pachycarpidine
OXYMATRINE
Kurainone
matrine,1-oxide
matrine n-oxide
Oxymatrine std.

Chemical & Physical Properties

[ Density]:
1.383g/cm3

[ Boiling Point ]:
415.7ºC at 760mmHg

[ Melting Point ]:
242-244ºC

[ Molecular Formula ]:
C17H16F6N2O

[ Molecular Weight ]:
378.31200

[ Flash Point ]:
205.2ºC

[ Exact Mass ]:
378.11700

[ PSA ]:
45.15000

[ LogP ]:
4.77670

[ Index of Refraction ]:
1.519

[ Storage condition ]:
Refrigerator, Under Inert Atmosphere

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC0333400
CHEMICAL NAME :
4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,S*)-(+-)-
CAS REGISTRY NUMBER :
53230-10-7
LAST UPDATED :
199701
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H16-F6-N2-O
MOLECULAR WEIGHT :
378.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
25 mg/kg/5W-I
TOXIC EFFECTS :
Behavioral - muscle weakness Musculoskeletal - joints Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 123,894,1995

Related Compounds

  • Mefloquine
  • (+)-Mefloquine
  • carboxymefloquine
  • carboxymefloquine
  • Mefloquine mesylate
  • N-Boc-(+)-mefloquine
  • 2-Bromo-1-(1-ethylcyclobutyl)ethan-1-ol
  • 3-chloro-N-[(4-hydroxy-3,4-dihydro-1H-2-benzothiopyran-4-yl)methyl]benzamide
  • N4-({3-[(2-chloro-4-fluorophenyl)methoxy]phenyl}methyl)-N1,N1-dimethylbenzene-1,4-diamine
  • 1-(4-{[5-(5-Fluoropyridin-2-yl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]sulfonyl}phenyl)pyrrolidine-2,5-dione
  • (2E)-N-[(4-hydroxy-3,4-dihydro-1H-2-benzothiopyran-4-yl)methyl]-3-phenylprop-2-enamide
  • 3-Chloro-2-{[1-(5-fluoro-2-methoxybenzenesulfonyl)piperidin-3-yl]methoxy}pyridine
  • N-[(4-hydroxy-3,4-dihydro-1H-2-benzothiopyran-4-yl)methyl]-2,3,4-trimethoxybenzamide
  • 2-[(4-fluorophenyl)sulfanyl]-N-[(4-hydroxy-3,4-dihydro-1H-2-benzothiopyran-4-yl)methyl]acetamide
  • 2-(1H-1,3-benzodiazol-1-yl)-1-[5-(5-chloropyridin-2-yl)-octahydropyrrolo[3,4-c]pyrrol-2-yl]ethan-1-one
  • 6-[5-(5-Bromopyridin-2-yl)-octahydropyrrolo[3,4-c]pyrrole-2-carbonyl]quinoxaline
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