MEFLOQUINE

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Names

[ CAS No. ]:
53230-10-7

[ Name ]:
MEFLOQUINE

[Synonym ]:
Pachycarpidine
OXYMATRINE
Kurainone
matrine,1-oxide
matrine n-oxide
Oxymatrine std.

Chemical & Physical Properties

[ Density]:
1.383g/cm3

[ Boiling Point ]:
415.7ºC at 760mmHg

[ Melting Point ]:
242-244ºC

[ Molecular Formula ]:
C17H16F6N2O

[ Molecular Weight ]:
378.31200

[ Flash Point ]:
205.2ºC

[ Exact Mass ]:
378.11700

[ PSA ]:
45.15000

[ LogP ]:
4.77670

[ Index of Refraction ]:
1.519

[ Storage condition ]:
Refrigerator, Under Inert Atmosphere

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
VC0333400
CHEMICAL NAME :
4-Quinolinemethanol, alpha-2-piperidinyl-2,8-bis(trifluoromethyl)-, (R*,S*)-(+-)-
CAS REGISTRY NUMBER :
53230-10-7
LAST UPDATED :
199701
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C17-H16-F6-N2-O
MOLECULAR WEIGHT :
378.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Human - woman
DOSE/DURATION :
25 mg/kg/5W-I
TOXIC EFFECTS :
Behavioral - muscle weakness Musculoskeletal - joints Skin and Appendages - dermatitis, other (after systemic exposure)
REFERENCE :
AIMEAS Annals of Internal Medicine. (American College of Physicians, 4200 Pine St., Philadelphia, PA 19104) V.1- 1927- Volume(issue)/page/year: 123,894,1995

Related Compounds

  • Mefloquine
  • (+)-Mefloquine
  • carboxymefloquine
  • carboxymefloquine
  • Mefloquine mesylate
  • N-Boc-(+)-mefloquine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 6-Aminopyridazine-4-carbonitrile
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 2-Bromo-5,6,7,8-tetrahydro-4H-thieno[3,2-b]azepine