1,2-Propanediol,3-(2-methylphenoxy)-, 1-carbamate

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Names

[ CAS No. ]:
533-06-2

[ Name ]:
1,2-Propanediol,3-(2-methylphenoxy)-, 1-carbamate

[Synonym ]:
2-hydroxy-3-(o-tolyloxy)propyl carbamate
2-Carbamoyloxy-3-o-tolyloxy-propan-1-ol
carbamic acid-(2-hydroxy-3-o-tolyloxy-propyl ester)
Mephenesin carbamate
1,2-Propanediol,3-(o-tolyloxy)-,1-carbamate
3-o-Toloxy-2-hydroxypropyl 1-carbamate
Tolseram
1-Hydrazinocarbonyloxy-3-(o-methylphenoxy)-2-propanol
Kimavoxyl
3-(o-Methylphenoxy)-1,2-propandiol-1-carbamat
Carbamidsaeure-(2-hydroxy-3-o-tolyloxy-propylester)
3-o-Tolyloxy-2-hydroxypropyl 1-carbamate
2-Hydroxy-3-o-tolyloxypropyl 1-carbamate
SQ 2303

Chemical & Physical Properties

[ Density]:
1.222g/cm3

[ Boiling Point ]:
461.4ºC at 760mmHg

[ Molecular Formula ]:
C11H15NO4

[ Molecular Weight ]:
225.24100

[ Flash Point ]:
232.8ºC

[ Exact Mass ]:
225.10000

[ PSA ]:
81.78000

[ LogP ]:
1.53030

[ Index of Refraction ]:
1.547

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
FB2710000
CHEMICAL NAME :
Carbamic acid, 2-hydroxy-3-(o-tolyloxy)propyl ester
CAS REGISTRY NUMBER :
533-06-2
BEILSTEIN REFERENCE NO. :
1880597
LAST UPDATED :
199612
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C11-H15-N-O4
MOLECULAR WEIGHT :
225.27
WISWESSER LINE NOTATION :
ZVO1YQ1OR B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1050 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
413 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1050 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
490 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
982 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - hamster
DOSE/DURATION :
385 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness Behavioral - ataxia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 129,75,1960

Safety Information

[ HS Code ]:
2924299090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • sodium,2-methylphenolate
  • phosgene
  • Mephenesin

DownStream

Customs

[ HS Code ]: 2924299090

[ Summary ]:
2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • CARBAMIC ACID, METHYL-, 2-HYDROXY-3-(o-TOLYLOXY)PROPYL ESTER
  • (S)-methocarbamol
  • (R)-methocarbamol
  • methocarbamol
  • 1,2-Propanediol,3-(2-nitro-1H-imidazol-1-yl)-
  • 1,2-Propanediol,3-(2,4,5-trichlorophenoxy)-, 1,2-diacetate
  • N-{5-[(E)-2-(5-{[(2,3-dimethylphenyl)amino]sulfonyl}-2-thienyl)vinyl]-3-methylisoxazol-4-yl}acetamide
  • 6-(((3-(3-chlorophenyl)-1,2,4-oxadiazol-5-yl)methyl)thio)-7-(furan-2-ylmethyl)-[1,3]dioxolo[4,5-g]quinazolin-8(7H)-one
  • 2,4-Bis(trichloromethyl)benzonitrile
  • ethyl 2-cyano-2-(5-oxo-5H-[1]benzopyrano-[2,3-b]pyridin-7-yl)propionate
  • N-[2-(isopropylamino)ethyl]-p-toluenesulfonamide
  • 3-[3-(N-methylacetamido)phenyl]propanoic acid
  • N-(4-{[4-(dimethylamino)-6-methylpyrimidin-2-yl]amino}phenyl)-2,5-diethoxybenzene-1-sulfonamide
  • 6-chloro-N-(4-fluorophenyl)-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 2-[4-(4-ethoxybenzoyl)piperazin-1-yl]-6-methyl-N-phenylpyrimidin-4-amine
  • N-cyclohexyl-2-((7-(4-ethoxyphenyl)-6,7-dihydro-5H-imidazo[2,1-c][1,2,4]triazol-3-yl)thio)acetamide
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