Clomethiazole

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Names

[ CAS No. ]:
533-45-9

[ Name ]:
Clomethiazole

[Synonym ]:
Clomethiazole
Emineurina
Clomethiazol
Chlormethiazole
MFCD00868012
Distraneurin
Clometiazole
Chlormethiazol
Clomethiazolum
EINECS 208-565-7

Chemical & Physical Properties

[ Density]:
1.218 g/cm3

[ Boiling Point ]:
245.8ºC at 760 mmHg

[ Molecular Formula ]:
C6H8ClNS

[ Molecular Weight ]:
198.11300

[ Flash Point ]:
102.4ºC

[ Exact Mass ]:
196.98300

[ PSA ]:
41.13000

[ LogP ]:
3.03480

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ3850000
CHEMICAL NAME :
Thiazole, 5-(2-chloroethyl)-4-methyl-
CAS REGISTRY NUMBER :
533-45-9
BEILSTEIN REFERENCE NO. :
0114244
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C6-H8-Cl-N-S
MOLECULAR WEIGHT :
161.66
WISWESSER LINE NOTATION :
T5N CSJ D2G E1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
2110 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 7,167,1964
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
190 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 8,39,1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
94 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
APSXAS Acta Pharmaceutica Suecica. (Apotekarsocieteten-Farmacevtiska Foereningen, Box 1136, S-111, 81 Stockholm, Sweden) V.1- 1964- Volume(issue)/page/year: 7,423,1970

Safety Information

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Sulfurol
  • 5-(2-ETHOXYETHYL)-4-METHYLTHIAZOLE
  • 2-Pentanone,3-chloro-5-ethoxy-
  • 3-chloro-5-hydroxypentan-2-one
  • 3,5-dichloropentan-2-one

DownStream

  • 5-Ethenyl-4-methylthiazole
  • 2-(4-Methyl-1,3-thiazol-5-yl)ethanamine

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Related Compounds

  • clomethiazole
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • N-(5-chloro-2,4-dimethoxyphenyl)-2-({4-oxo-3-propyl-3H,4H-thieno[3,2-d]pyrimidin-2-yl}sulfanyl)acetamide
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1-(Naphthalen-1-yl)-1H-1,2,3-triazole-5-carboxylic acid
  • 3-(benzylsulfonyl)-N-(4-methoxynaphthalen-1-yl)propanamide
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • [4-(2,1,3-Benzothiadiazol-4-ylsulfonyl)piperazin-1-yl](phenyl)methanone