dethiobiotin

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Names

[ CAS No. ]:
533-48-2

[ Name ]:
dethiobiotin

[Synonym ]:
DL-DESTHIOBIOTIN
6-[(4R,5S)-5-Methyl-2-oxo-4-imidazolidinyl]hexanoic acid
6-(5-methyl-2-oxo-imidazolidin-4-yl)hexanoic acid
4-Imidazolidinehexanoic acid, 5-methyl-2-oxo-, (4R,5S)-
(4R-cis)-5-methyl-2-oxoimidazolidine-4-hexanoic acid
Desthiobiotin
1H-Imidazole-5-hexanoic acid, 4,5-dihydro-2-hydroxy-4-methyl-, (4S,5R)-
dethiobiotin
d-Desthiobiotin
5-METHYL-2-OXO-4-IMIDAZOLINE-CAPROIC ACID
[4R,5S,(+)]-5-Methyl-2-oxo-4-imidazolidinehexanoic acid
5-Methyl-2-oxo-4-imidazolidinehexanoic acid
D(-)-desthiobiotin
(4R,5S)-dethiobiotin
6-[(4R,5S)-5-Methyl-2-oxoimidazolidin-4-yl]hexanoic acid

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
476.4±18.0 °C at 760 mmHg

[ Melting Point ]:
156-158 °C

[ Molecular Formula ]:
C10H18N2O3

[ Molecular Weight ]:
214.262

[ Flash Point ]:
241.9±21.2 °C

[ Exact Mass ]:
214.131744

[ PSA ]:
78.43000

[ LogP ]:
0.31

[ Vapour Pressure ]:
0.0±2.6 mmHg at 25°C

[ Index of Refraction ]:
1.473

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • phosgene
  • D-Biotin

DownStream

  • 2,5-Dioxopyrrolidin-1-yl 6-((4R,5S)-5-methyl-2-oxoimidazolidin-4-yl)hexanoate

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Easily reversible desthiobiotin binding to streptavidin, avidin, and other biotin-binding proteins: uses for protein labeling, detection, and isolation.

Anal. Biochem. 308 , 343-357, (2002)

The high-affinity binding of biotin to avidin, streptavidin, and related proteins has been exploited for decades. However, a disadvantage of the biotin/biotin-binding protein interaction is that it is...

Direct binding of triglyceride to fat storage-inducing transmembrane proteins 1 and 2 is important for lipid droplet formation.

Proc. Natl. Acad. Sci. U. S. A. 108(49) , 19581-19586, (2011)

The process of lipid droplet (LD) formation is an evolutionarily conserved process among all eukaryotes and plays an important role in both cellular physiology and disease. Recently, fat storage-induc...

Mutagenesis of a flexible loop in streptavidin leads to higher affinity for the Strep-tag II peptide and improved performance in recombinant protein purification.

Protein Eng. 10(8) , 975-982, (1997)

The Strep-tag, an artificial peptide ligand of streptavidin, has gained use as an affinity handle for the purification and detection of recombinant fusion proteins. In an attempt to achieve tighter co...


More Articles

Related Compounds

  • dethiobiotin
  • dethiobiotin
  • dl-dethiobiotine
  • dethiobiotin N-hydroxysuccinimide ester
  • 5-Amino-1-[(2-ethylcyclopropyl)methyl]-4-methyl-1,2-dihydropyridin-2-one
  • 6-(4-methanesulfonyl-1H-pyrazol-1-yl)pyrazine-2-carboxylic acid
  • N-cyclopropyl-1-{3-methyl-3H-imidazo[4,5-b]pyridin-2-yl}piperidine-4-carboxamide
  • N-cyclopropyl-1-{7-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-yl}piperidine-4-carboxamide
  • tert-butyl N-[2-amino-3-(2,5-dimethylthiophen-3-yl)propyl]carbamate
  • 4-(4-methanesulfonyl-1H-pyrazol-1-yl)-6-methylpyridine-3-carboxylic acid
  • 3-bromo-4-(4-methanesulfonyl-1H-pyrazol-1-yl)benzoic acid
  • N-methyl-N-[1-(4-methyl-1,3-thiazol-2-yl)piperidin-4-yl]pyridin-2-amine
  • N-cyclopropyl-1-{thieno[2,3-d]pyrimidin-4-yl}piperidine-4-carboxamide
  • 3-(5-chloro-1H-indol-2-yl)oxolane-2,5-dione
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