1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

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Names

[ CAS No. ]:
5334-99-6

[ Name ]:
1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine

[Synonym ]:
1-methylpyrazolo[3,4-d]pyrimidin-4-amine
1-Methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-methyl-

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
354.4±22.0 °C at 760 mmHg

[ Melting Point ]:
268-270ºC

[ Molecular Formula ]:
C6H7N5

[ Molecular Weight ]:
149.153

[ Flash Point ]:
168.2±22.3 °C

[ Exact Mass ]:
149.070145

[ PSA ]:
69.62000

[ LogP ]:
-0.49

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.807

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UR0718000
CHEMICAL NAME :
1H-Pyrazolo(3,4-d)pyrimidine, 4-amino-1-methyl-
CAS REGISTRY NUMBER :
5334-99-6
BEILSTEIN REFERENCE NO. :
0149930
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C6-H7-N5
MOLECULAR WEIGHT :
149.18
WISWESSER LINE NOTATION :
T56 BNN GN INJ B1 FZ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
45 mg/kg
SEX/DURATION :
female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Specific Developmental Abnormalities - body wall Reproductive - Specific Developmental Abnormalities - musculoskeletal system
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 247,152,1958
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
45 mg/kg
SEX/DURATION :
female 7-9 day(s) after conception
TOXIC EFFECTS :
Reproductive - Effects on Embryo or Fetus - fetal death
REFERENCE :
COREAF Comptes Rendus Hebdomadaires des Seances, Academie des Sciences. (Paris, France) V.1-261, 1835-1965. For publisher information, see CRASEV. Volume(issue)/page/year: 247,152,1958

Safety Information

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 4-Chloro-1-methyl-1H-pyrazolo[3,4-d]pyrimidine
  • 5-amino-4-cyano-1-methyl-1,2-pyrazole
  • (Z)-Methanimidic acid

DownStream

  • 1-methyl-4-phenylpyrazolo[3,4-d]pyrimidine
  • 1-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE
  • 1-methyl-4-(pentyloxy)-1H-pyrazolo(3,4-d)pyrimidine
  • 1-methyl-4-(m-chlorophenyl)pyrazolo(3,4-d)pyrimidine
  • 1-methyl-4-(o-chlorophenyl)pyrazolo(3,4-d)pyrimidine
  • 1-methyl-4-(m-anisyl)pyrazolo(3,4-d)pyrimidine
  • 1-methyl-4-(p-anisyl)pyrazolo(3,4-d)pyrimidine
  • 1-methyl-4-(o-anisyl)pyrazolo(3,4-d)pyrimidine
  • 1-methyl-4-(m-methylphenyl)pyrazolo(3,4-d)pyrimidine
  • 1-methyl-4-(p-methylphenyl)pyrazolo(3,4-d)pyrimidine

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-hexyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 3-BROMO-1-METHYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
  • 6-chloro-1-methyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine
  • 6-benzyl-1-methyl-1h-pyrazolo[3,4-d]pyrimidin-4-amine
  • 6-Methoxy-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • N,N-diethyl-1-methyl-1H-pyrazolo[3,4-d]pyrimidin-4-amine
  • 2-(3-Methylpyrazin-2-yl)ethane-1-thiol
  • (2S)-5-(1H-1,3-benzodiazol-2-yl)pentan-2-ol
  • (2R)-1-(2-methoxy-1,3-thiazol-5-yl)propan-2-amine
  • 2-Methyl-3-oxoisoindoline-4-carbonitrile
  • 4,6,10-Dodecatrien-3-one, 7,11-dimethyl-, (Z,E)-
  • (R)-1-(4,5-Dimethylthiazol-2-yl)ethanol
  • tert-Butyl (R)-2-(2-ethoxy-2-oxoethylidene)-5-methylpyrrolidine-1-carboxylate
  • tert-butyl (R)-2-((4-cyanobenzyl)carbamoyl)pyrrolidine-1-carboxylate
  • Acetic acid, 2-[[2-[(3,4-dichlorophenyl)amino]-6-phenyl-4-pyrimidinyl]oxy]-
  • Acetic acid, 2-[[2-[[(4-chlorophenyl)methyl]amino]-6-(trifluoromethyl)-4-pyrimidinyl]oxy]-
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