NEOPYRITHIAMINE HYDROBROMIDE

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Names

[ CAS No. ]:
534-64-5

[ Name ]:
NEOPYRITHIAMINE HYDROBROMIDE

[Synonym ]:
neopyrithiamine hydrobromide

Chemical & Physical Properties

[ Molecular Formula ]:
C14H20Br2N4O

[ Molecular Weight ]:
420.14300

[ Exact Mass ]:
418.00000

[ PSA ]:
75.91000

[ Appearance of Characters ]:
crystalline | off-white to yellow

[ Storage condition ]:
2-8°C

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H312-H332

[ Precautionary Statements ]:
P280

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/21/22

[ Safety Phrases ]:
36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-Pyridineethanol,2-methyl-
  • 4-Pyrimidinamine, 5-(bromomethyl)-2-methyl-, monohydrobromide

DownStream

Articles

Interactions between chronic ethanol consumption and thiamine deficiency on neural plasticity, spatial memory, and cognitive flexibility.

Alcohol. Clin. Exp. Res. 39 , 2143-53, (2015)

Many alcoholics display moderate to severe cognitive dysfunction accompanied by brain pathology. A factor confounded with prolonged heavy alcohol consumption is poor nutrition, and many alcoholics are...

Identification of the antiphagocytic trypacidin gene cluster in the human-pathogenic fungus Aspergillus fumigatus.

Appl. Microbiol. Biotechnol. 99 , 10151-61, (2015)

The opportunistic human pathogen Aspergillus fumigatus produces numerous different natural products. The genetic basis for the biosynthesis of a number of known metabolites has remained unknown. The g...

Thiamine deficiency caused by thiamine antagonists triggers upregulation of apoptosis inducing factor gene expression and leads to caspase 3-mediated apoptosis in neuronally differentiated rat PC-12 cells.

Acta Biochim. Pol. 54(2) , 315-22, (2007)

Recent evidence suggests that alterations in oxidative metabolism induced by thiamine deficiency lead to neuronal cell death. However, the molecular mechanisms underlying this process are still under ...


More Articles

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