1-(Piperidinomethyl)-2-naphthol

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Names

[ CAS No. ]:
5342-95-0

[ Name ]:
1-(Piperidinomethyl)-2-naphthol

[Synonym ]:
piperidinomethyl-2-naphthol
1-piperidinomethylene-2-naphthol
1-Piperidinomethyl-[2]naphthol
Ro 3-0514
1-piperidin-1-ylmethyl-naphthalen-2-ol
1-PIPERIDINOMETHYL-2-NAPHTHOL
1-(piperidin-1-ylmethyl)-2-naphthol

Chemical & Physical Properties

[ Density]:
1.158g/cm3

[ Boiling Point ]:
393.2ºC at 760mmHg

[ Melting Point ]:
93ºC

[ Molecular Formula ]:
C16H19NO

[ Molecular Weight ]:
241.32800

[ Flash Point ]:
198.8ºC

[ Exact Mass ]:
241.14700

[ PSA ]:
23.47000

[ LogP ]:
3.46920

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QL4905000
CHEMICAL NAME :
2-Naphthol, 1-(piperidinomethyl)-
CAS REGISTRY NUMBER :
5342-95-0
BEILSTEIN REFERENCE NO. :
0185859
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C16-H19-N-O
MOLECULAR WEIGHT :
241.36

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
46 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - changes in structure or function of salivary glands
REFERENCE :
BJPCAL British Journal of Pharmacology and Chemotherapy. (London, UK) V.1-33, 1946-68. For publisher information, see BJPCBM. Volume(issue)/page/year: 12,194,1957
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 73,27,1941

Safety Information

[ HS Code ]:
2933399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Piperidine
  • Formaldehyde
  • 2-Naphthol
  • 3-Hydroxy-2,2-dimethylpropanal
  • DIPIPERIDINOMETHANE
  • piperidin-1-ylmethanol
  • Piperidine, 1-(ethoxymethyl)- (8CI)(9CI)

DownStream

  • 1-methyltetralin-2-ol

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • N-(1-(2-naphthol))phosphatidylethanolamine
  • 1-[(4-ethylpiperidin-1-yl)methyl]naphthalen-2-ol
  • 3-Nitrophenol-(6-azo-1)-2-naphthol-3,6-disulfonsaeure
  • 3-amino-4-[[(Z)-4-[4-(piperidin-1-ylmethyl)pyridin-2-yl]oxybut-2-enyl]amino]cyclobut-3-ene-1,2-dione,hydrochloride
  • 2-(piperidin-1-ylmethyl)cyclohexan-1-ol,hydrochloride
  • 9-methyl-3-(piperidin-1-ylmethyl)-2,3-dihydro-1H-carbazol-4-one
  • 2-(5-{[(9H-fluoren-9-yl)methoxy]carbonyl}-5-azaspiro[3.5]nonan-8-yl)acetic acid
  • methyl 5-amino-1-(pyridazin-3-yl)-1H-pyrazole-4-carboxylate
  • Methyl 3,3-dimethyl-1,2,3,4-tetrahydroisoquinoline-1-carboxylate
  • 2-{[(Tert-butoxy)carbonyl]amino}-3-iodo-5-(trifluoromethyl)benzoic acid
  • 2-{[(Benzyloxy)carbonyl]amino}-4,5,6,7-tetrahydro-1,3-benzothiazole-4-carboxylic acid
  • 2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)imidazo[1,2-a]pyridine-5-carboxylic acid
  • 3-{[(Tert-butoxy)carbonyl]amino}-2-(propan-2-yloxy)benzoic acid
  • 3-{[(Benzyloxy)carbonyl]amino}-3-(2-fluorophenyl)butanoic acid
  • rac-ethyl (1R,5R)-5-methyl-3-azabicyclo[3.1.0]hexane-1-carboxylate
  • rac-tert-butyl (1R,5R)-5-methyl-3-azabicyclo[3.1.0]hexane-1-carboxylate
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