Diaveridine

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Names

[ CAS No. ]:
5355-16-8

[ Name ]:
Diaveridine

[Synonym ]:
Diaveridinum [INN-Latin]
Diaveridinum
DIAVERIDINE
2,4-Diamino-5-veratrylpyrimidine
5-(3,4-Dimethoxybenzyl)-2,4-pyrimidinediamine
2,4-diamino-5-(3,4-dimethoxy-benzyl)-pyrimidine
MFCD00057349
5-(3,4-dimethoxy-benzyl)-pyrimidine-2,4-diamine
5-[(3,4-dimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Diaveridin
BW 49-210
Diaveridina
5-Veratryl-pyrimidin-2,4-diyldiamin
EINECS 226-333-3

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
506.1±60.0 °C at 760 mmHg

[ Melting Point ]:
232 - 236ºC

[ Molecular Formula ]:
C13H16N4O2

[ Molecular Weight ]:
260.292

[ Flash Point ]:
259.9±32.9 °C

[ Exact Mass ]:
260.127319

[ PSA ]:
96.28000

[ LogP ]:
1.09

[ Vapour Pressure ]:
0.0±1.3 mmHg at 25°C

[ Index of Refraction ]:
1.626

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UV8142000
CHEMICAL NAME :
2,4-Pyrimidinediamine, 5-((3,4-dimethoxyphenyl)methyl)-
CAS REGISTRY NUMBER :
5355-16-8
BEILSTEIN REFERENCE NO. :
0258464
LAST UPDATED :
199612
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C13-H16-N4-O2
MOLECULAR WEIGHT :
260.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3679 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
6028 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
5 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 261,149,1991

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
2

[ RTECS ]:
UV8142000

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2-Dimethoxybenzene
  • Carbon
  • 2,4-Diamino-5-methoxymethylpyrimidine
  • 3-Anilino-2-veratrylacrylonitrile
  • Guanidine hydrochloride
  • veratraldehyde
  • 3-Morpholino-2-veratrylacrylonitrile

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

[Polarographic determination of diaveridine in biological samples].

Acta Pharm. Hung. 60(1) , 23-9, (1990)

Differential pulse polarographic method was applied for determination of diaveridine in plasma, whole blood and isolated organs (liver, spleen, kidney, thymus). Deproteinization of homogenized blood a...

Inhibitors of folic acid synthesis in the treatment of experimental Pneumocystis carinii pneumonia.

Antimicrob. Agents Chemother. 32(1) , 96-103, (1988)

Inhibitors of folic acid synthesis were compared alone and in different combinations in the therapy of pneumocystosis in immunosuppressed rats. Sulfonamides (sulfamethoxazole, sulfadiazine, and sulfad...

Demonstration of synergistic effects of sulfonamides and dihydrofolate reductase/thymidylate synthase inhibitors against Neospora caninum tachyzoites in cultured cells, and characterization of mutants resistant to pyrimethamine.

Am. J. Vet. Res. 57(1) , 68-72, (1996)

To examine the efficacies of combinations of 7 sulfonamides and 5 dihydrofolate reductase/thymidylate synthase (DHFR/TS) inhibitors against tachyzoites of Neospora caninum in cultured cells. Mutant ta...


More Articles

Related Compounds

  • N-ethyl-2-{4-[(2-phenyl-1,3-thiazol-4-yl)methyl]piperazin-1-yl}pyrimidin-4-amine
  • N-(1-{5H,6H,7H-cyclopenta[d]pyrimidin-4-yl}piperidin-3-yl)-N,2,2-trimethylpropanamide
  • 4-Cyclobutyl-6-{4-[(3,6-dimethylpyrazin-2-yl)oxy]piperidin-1-yl}pyrimidine
  • 2-[1-({5H,6H,7H-pyrrolo[2,1-c][1,2,4]triazol-3-yl}methyl)-octahydropyrrolo[3,4-b]pyrrol-5-yl]-4-(trifluoromethyl)pyridine
  • tert-butyl (2S)-2-(2-methylprop-2-enoyl)pyrrolidine-1-carboxylate
  • tert-butyl N-[1-(3-ethoxy-2-oxopropyl)cyclopropyl]carbamate
  • tert-butyl N-[2-methyl-2-(prop-2-ynoyl)cyclopentyl]carbamate
  • tert-butyl N-[3-(2-methylcyclopropyl)-2-oxopropyl]carbamate
  • 3-Methyl-4-[4-(propan-2-yl)phenyl]pyrrolidin-3-amine
  • 5-(chloromethyl)-4-(4-methanesulfonyl-1H-pyrazol-1-yl)-2-methoxy-1,3-thiazole