β-ACETYLDIGOXIN

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Names

[ CAS No. ]:
5355-48-6

[ Name ]:
β-ACETYLDIGOXIN

[Synonym ]:
Cardioreg
Digotab
ACETYLDIGOXIN,B
novodigal
Cor-puren
digoridb
B-ACETYLDIGOXIN
Beta-Acetyl Digoxin

Chemical & Physical Properties

[ Density]:
1.34 g/cm3

[ Boiling Point ]:
930.3ºC at 760 mmHg

[ Melting Point ]:
271-273ºC

[ Molecular Formula ]:
C₄₃H₆₆O₁₅

[ Molecular Weight ]:
822.97500

[ Flash Point ]:
273.6ºC

[ Exact Mass ]:
822.44000

[ PSA ]:
209.13000

[ LogP ]:
2.78890

[ Index of Refraction ]:
1.59

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: IH6330000

CHEMICAL NAME :: Digoxin, acetate, beta-

CAS REGISTRY NUMBER :: 5355-48-6

LAST UPDATED :: 199712

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C43-H66-O15

MOLECULAR WEIGHT :: 823.09

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - child

DOSE/DURATION :: 372 ug/kg

TOXIC EFFECTS :: Cardiac - EKG changes not diagnostic of specified effects Cardiac - pulse rate Nutritional and Gross Metabolic - changes in potassium

REFERENCE :: ICMED9 Intensive Care Medicine. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 07094) V.3- 1977- Volume(issue)/page/year: 4,199,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 422 ug/kg

TOXIC EFFECTS :: Behavioral - muscle contraction or spasticity Gastrointestinal - nausea or vomiting

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 24,1914,1974

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 285 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,687,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraduodenal

SPECIES OBSERVED :: Mammal - cat

DOSE/DURATION :: 413 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,687,1969

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 2400 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,481,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: 1380 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 15,483,1965

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Bird - pigeon

DOSE/DURATION :: 387 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 21,225,1971 *** REVIEWS *** TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,187,1963 TOXICOLOGY REVIEW 85ELDJ "Die Herzwirksamen Glykoside," Baumgarten, G., and W. Forster, Leipzig, Ger. Dem. Rep., VEB Georg Thieme, 1963 Volume(issue)/page/year: -,54,1963

Safety Information

[ RIDADR ]:
UN 3249

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

Precursor & DownStream

Precursor

Acetyl chloride
digoxin
Lanatoside C
α-Acetyl Digoxin

DownStream

digoxin
Digoxigenin

Related Compounds

β,γ-epoxy-isovaleric acid ethyl ester
β-Butoxyvinylphosphonsaeure-dichloroanhydrid
β,6-dimethyl-7-oxabicyclo[4.1.0]heptane-3-ethyl acetate
β-(Iodzinkio)propionsaeureethylester
β-phenethyl ferulate
β-(N-Methyl-2-methyl-3-indolyl)styrene
(3-Methoxy-1,2-oxazol-5-yl)methanesulfonyl fluoride
(R)-3-(1-Amino-2-methylpropyl)-5-fluoropyridin-2(1H)-one
rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 1-[(3R,4R)-4-({[(tert-butoxy)carbonyl]amino}methyl)oxolan-3-yl]-1H-1,2,3-triazole-4-carboxylate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 1-(4-ethylphenyl)-1H-1,2,3-triazole-4-carboxylate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 3-[3-(trifluoromethyl)phenyl]butanoate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-(6-methoxy-1,2,3,4-tetrahydronaphthalen-1-yl)acetate
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 6-[({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)methyl]-2-methylpyridine-3-carboxylate
3-iodo-1H-indazol-7-aminedihydrochloride
1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 6-[(2-{[(tert-butoxy)carbonyl]amino}phenyl)carbamoyl]pyridine-3-carboxylate
1,1,1-trifluoro-3-(1H-pyrrol-2-yl)propan-2-amine

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