2-Bromo-4'-chloroacetophenone

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Names

[ CAS No. ]:
536-38-9

[ Name ]:
2-Bromo-4'-chloroacetophenone

[Synonym ]:
α-Bromo-p-chloroacetophenone
MFCD00000625
Ethanone, 2-bromo-1-(4-chlorophenyl)-
ω-Bromo-4-chloroacetophenone
2-Bromo-4‘-chloroacetophenone
2-Bromo-4'-chloroacetophenone
α-Bromo-4-chloroacetophenone
4'-Chloro-2-Bromoacetophenone
4-Chlorophenacyl Bromide
EINECS 208-631-5
2-Bromo-1-(4-chlorophenyl)ethanone
Ethanone, 2-bromo-1- (4-chlorophenyl)-
α-Bromo-4'-chloroacetophenone
2-bromo-1-(4-chlorophenyl)ethan-1-one

Chemical & Physical Properties

[ Density]:
1.6±0.1 g/cm3

[ Boiling Point ]:
289.7±15.0 °C at 760 mmHg

[ Melting Point ]:
95-99ºC

[ Molecular Formula ]:
C8H6BrClO

[ Molecular Weight ]:
233.490

[ Flash Point ]:
129.0±20.4 °C

[ Exact Mass ]:
231.929047

[ PSA ]:
17.07000

[ LogP ]:
2.88

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AM5978800
CHEMICAL NAME :
Acetophenone, 2-bromo-4'-chloro-
CAS REGISTRY NUMBER :
536-38-9
BEILSTEIN REFERENCE NO. :
0607603
LAST UPDATED :
199709
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H6-Br-Cl-O
MOLECULAR WEIGHT :
233.50

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>2 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
MEXPAG Medicina Experimentalis. (Basel, Switzerland) V.1-11, 1959-64; V.18-19, 1968-69. For publisher information, see JNMDBO. Volume(issue)/page/year: 11,137,1964

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R22;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
AM5978800

[ Packaging Group ]:
III

[ HS Code ]:
2914399090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1-(4-Chlorophenyl)ethanone
  • 1-bromo-2-(4-chlorophenyl)acetylene
  • 4-Chlorostyrene
  • 1-Chloro-4-Ethylbenzene
  • 1-(4-Chlorophenyl)ethanol
  • 2-bromo-1-(4-chlorophenyl)ethanol
  • ethyl acetate
  • 2,2-Dibromo-1-(4-chlorophenyl)ethanone
  • Bromoacetyl chloride

DownStream

  • 3-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]quinazolin-4-one
  • 1-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]pyridin-2-one
  • 1-[3-(4-chlorophenyl)-1-(4-fluorophenyl)-3-oxoprop-1-en-2-yl]pyridin-2-one
  • 5-(4-CHLOROPHENYL)-3-HYDROXYMETHYL-2-METHYLFURAN
  • 1-[1-(4-chlorophenyl)-1-oxopent-2-en-2-yl]pyridin-2-one
  • 5-chloro-1-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]pyridin-2-one
  • 2-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]phthalazin-1-one
  • 1-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]quinolin-2-one
  • 2-[1-[2-(4-chlorophenyl)-2-oxoethyl]-5-methoxy-2-methylindol-3-yl]acetic acid
  • 3-[3-(4-chlorophenyl)-3-oxoprop-1-en-2-yl]pyrimidin-4-one

Customs

[ HS Code ]: 2914399090

[ Summary ]:
2914399090. other aromatic ketones without other oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:5.5%. General tariff:30.0%

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Related Compounds

  • 2-Bromo-4'-chloroacetophenone
  • 2-Bromo-4'-chloroacetophenone
  • 2-BROMO-1-(3-BROMO-4-CHLORO-PHENYL)-ETHANONE
  • 2-Bromo-1-(4-chloro-3-methylphenyl)ethan-1-one
  • (2-BROMO-4'-TRIFLUOROMETHYL-BIPHENYL-4-YL)-ACETIC ACID METHYL ESTER
  • 2-bromo-4'-hydroxyphenyl acetic acid
  • 1,1,1-Trifluoro-3-methanesulfonylpropan-2-amine
  • 1-(3-Chloro-5-fluorophenyl)-2,2-difluoroethan-1-amine
  • 3-Chloro-4-hydrazinyl-2-methylpyridine
  • Cbgb
  • 3-[4-Hydroxy-4-(trifluoromethyl)azepan-1-yl]sulfonylpyridine-2-carbonitrile
  • 4-Azido-3-chloro-2-methylpyridine
  • 5-(3-Bromopyridin-4-yl)-1,2,4-oxadiazole-3-carboxylic acid
  • 5-(3-Chloro-5-methylphenyl)thiazol-2-amine
  • Nc1ccn(n1)-c1ccnc(c1)C(F)F
  • ({[4-(Bromomethyl)-4-methylhex-5-en-1-yl]oxy}methyl)benzene